文档介绍：晚期食管癌不同化疗方案疗效对比[ 摘要] 目的分析***尿嘧啶类、紫杉类、铂类药物不同组合方案在晚期食管癌治疗中的效果及毒副作用,探讨晚期食管癌最佳药物治疗方案。方法回顾分析 2009 年9 月~ 2012 年5 月扬州市第一人民医院治疗的 97 例晚期或复发转移食管癌患者的临床资料。按其化疗方案进行分组, 将采用***尿嘧啶联合铂类、***尿嘧啶类联合紫杉类、紫杉类联合铂类以及三药联合方案治疗的患者分为 A( 22例)、B( 21例)、C( 39例)、D(15 例) 四组, 分析各组疗效及毒副作用。结果四组患者客观有效率分别为 % 、 % 、 % 、 % ,差异无统计学意义( P> ) 。远期疗效分析, 四组进展生存期、总生存期比较, 差异均无统计学意义(P> ), 尽管三药联合方案在一定程度上提高了中位无进展生存期, 但差异无统计学意义( P> ) 。对一线治疗患者进行分层分析,各组间差异均无统计学意义( P> ) 。各组化疗相关毒副作用均主要为骨髓抑制、恶心呕吐及便秘,D 组腹泻和手足综合征发生例数较 C 组明显增加(P< )。结论***尿嘧啶、紫杉类、铂类药物不同组合方案在晚期食管癌治疗中效果并无明显差异, 化疗相关不良反应表现不同, 三药联合方案毒副作用发生率较高,对体力状况评分较好患者可谨慎使用。[ 关键词] 食管癌;化学治疗;***尿嘧啶;铂类;紫杉类[ 中图分类号] [ 文献标识码]A[ 文章编号] 1673-7210 ( 2014 ) 11(b) -0042-05 [Abstract] Objective To analyze efficacy and side effects of Fluorouracil , Taxane , and binations in the treatment of advanced esophageal poisoning , and explore the best drug treatment mode. Methods A total of 97 cases of advanced or recurrent esophageal cancer from September 2009 to May 2012 in the First People's Hospital of Yangzhou City were retrospectively analyzed ; patients were divided into four groups according to their regimen : 22 cases of bined with Platinum ( group A), 21 cases of bined with Taxane ( group B), 15 cases of bined with Platinum ( group C) and 39 cases of three drugs ( group D). The efficacy and toxicity were assessed. Results Objective response rates of group A,B,C,D were % , % , % and % respectively , there was no statistically significant difference in four groups (P> ). Analysis of long-term effects , four groups had no statistically significant difference in PFS and OS(P> ), although the three drugs scheme improved the mPFS ina certain extent. Stratified analysis for the patients with first-line treatment , there were also no significant differences between groups (P> ). Chemotherapy-related toxicities were mainly myelosuppression , nausea , vomiting and constipation. Compared with group C, Incidences of diarrhea and hand-foot