文档介绍：中国热带医学2014年第14卷第09期China Tropical Medicine,September2014,,·短篇论著·邯郸市2013年初、复治涂阳肺结核患者耐药状况分析冯文海邯郸市疾病预防控制中心,河北邯郸056008摘要:目的分析邯郸市初、复治肺结核患者耐药状况,为结核病的临床和控制提供参考依据。方法对邯郸市2013年间登记的348例涂阳肺结核患者痰标本经培养阳性并作菌株鉴定。用比例法对结核分枝杆菌进行抗异烟肼(H)、利福平(R)、链霉素(S)和乙***丁醇(E)的耐药性检测,并分析结核分枝杆菌的耐药状况。结果348例结核分枝杆菌感染的涂阳肺结核患者中,%,%。复治组耐药率及耐多药率均高于初治组,差异有统计学意义(χ=,χ=,P<)。对4种抗结核药物的耐药频度由高到低依次为H(%)、S(%)、R(%)、E(%)。初治组对4种抗结核药物的耐药率较复治组低,差异均有统计学意义(P<)。结论邯郸市肺结核患者结核分枝杆菌耐药发生率高,需进一步加强耐药结核病的检测和防控。关键词:结核/肺;结核分枝杆菌;耐多药中图分类号:R521文献标识码:A文章编号:1009-9727(2014)9-1129-02Analysis of drug resistance in initial and retreated smear-positive tuberculosis patients inHandan city in2013FENG Wen-haiHandan Municipal Center for Disease Control and Prevention , Handan056008, Hebei, .ChinaAbstract: ObjectiveTo analyze the drug resistance of positive pulmonary tuberculosis (TB) patients registered inHandan and to provide the reference for clinical therapy and control of culture and strainidentification of348smear-positive TB patients registered in Handan during2013were conducted and the drug susceptibilityof themycobacteriumstrains to isoniazid (H), rifampicin (R), streptomycin (S) and ethambutol (E) were also performed by usingproportion method. The data were analyzed with total resistance rate and the multi-drugresistance (MDR) rates ofmycobacter