文档介绍：J South Med Univ, 2021, 41(9): 1409-1414 doi .1673-
改善PBDE-47所致PC12细胞异常自噬与凋亡，进而提高细胞存活。
关键词：褪黑素；PBDE-47；神经毒性；细胞自噬；细胞凋亡
Effects of melatonin on PBDE- 47- induced abnormal autophagy and apoptosis in PC12
cells
XIAO Boya1, DONG Lixin1, GAO Hui2, YANG Kaichao1, WANG Yafei1, LI Xiaoning1, QIU Haixia1, WANG Aiguo1, ZHANG Shun1
1Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, School of Public
Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2Department of Clinical Nutrition,
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract: Objective To explore the effect of melatonin (MT) on 2,2',4,4'-tetrabromodiphenylether (PBDE-47)-induced abnormal
autophagy and apoptosis in rat adrenal medullary pheochromocytoma PC12 cells. Methods PC12 cells were pretreated with a
concentration gradient (, 25, 50, 100, and 200 μmol/L) of melatonin for 2 h before exposure to 20 μmol/L PBDE-47 for 24 h
to determine the optimal concentration of melatonin for cell treatment. In subsequent experiments, PC12 cells were treated
with ‰ DMSO (control group), 20 μm