文档介绍：Richetti et al. Radiation Oncology 2010, 5:14
.com/content/5/1/14
RESEARCH Open Access
Neo-adjuvant chemo-radiation of rectal cancer
with Volumetric Modulated Arc Therapy:
summary of technical and dosimetric features
and early clinical experience
Antonella Richetti1, Antonella Fogliata2, Alessandro Clivio2, ia Nicolini2, Gianfranco Pesce1, Emanuela Salati1,
Eugenio ti2, Luca Cozzi2*
Abstract
Background: To report about initial technical and clinical experience in preoperative radiation treatment of rectal
cancer with volumetric modulated arcs with the RapidArc® (RA) technology.
Methods: Twenty-five consecutive patients (pts) were treated with RA. All showed locally advanced rectal
adenocarcinoma with stage T2-T4, N0-1. Dose prescription was 44 Gy in 22 fractions (or 45 Gy in 25 fractions).
Delivery was performed with single arc with a 6 MV photon beam. Twenty patients were treated preoperatively,
five did not receive surgery. Twenty-three patients received itant chemotherapy with oral capecitabine. A
comparison with a cohort of twenty patients with similar characteristics treated with conformal therapy (3DC) is
presented as well.
Results: From a dosimetric point of view, RA improved conformality of doses (CI95% = vs. for RA and 3DC),
presented similar target coverage with lower maximum doses, significant sparing of femurs and significant