文档介绍：小金胶囊联合硒酵母治疗甲状腺功能正常的桥本甲状腺炎的临床观察
摘要 目的:觀察小金胶囊( g/粒)联合硒酵母治疗甲状腺功能正常的桥本甲状腺炎的效果。方法:选取2016年6月至2018年6月武汉市中医医院收治的伴有甲状腺ps,there was no significant change in thyroid function and no significant decrease in the maximum diameter of the nodule (P>),but there was a downward trend in the maximum diameter of the nodule in the observation with the control group,TCM symptom score of the observation group was significantly reduced (P<),and TG-Ab and TPO-Ab levels and thyroid diameter lines were significantly reduced,with statistically significant differences (P<).The curative efficiency of the observation group was better than the control group (P<),and there was no statistically significant difference in thyroid function and maximum nodule :For patients with normal thyroid function of Hashimoto thyroiditis,Xiaojin Capsules combined with selenium yeast treatment can effectively improve symptoms,reduce the size of thyroid and decrease the level of thyroid autoantibody,with high function was not significantly affected,but nodule size had a decreased tendency. Key Words Xiaojin Capsules; Selenium teast; Thyroid function; Hashimoto thyroiditis
中图分类号:R259文献标识码:Adoi:.1673-
桥本甲状腺炎(Hashimoto′s Thyroiditis,HT)又称慢性淋巴细胞性甲状腺炎,属于自身免疫性甲状腺疾病,好发于30~50岁的女性,发病率随年龄增大而增高。甲状腺功能正常的HT患者多为初发患者,表现为咽部异物感、乏力、胸胁胀闷等轻微症状,伴有不同程度的甲状腺肿大,甲状腺过氧化物酶抗体(TPO-Ab)和甲状腺球蛋白抗体(TG-Ab)阳性。目前HT的治疗方法主要是根据甲状腺功能的异常,如对甲状腺功能亢进或甲状腺功能减退期进行相应治疗。而对于甲状腺功能正常的HT患者,根据2008年《中国甲状腺疾病诊治指南》中的HT诊治指南[1],往往采取随诊观察而无需特殊治疗。HT作为一种自身免疫性甲状腺疾病,一般不会自愈,并随着病情的发展,最终都会导致甲减,甲状腺肿大及压迫症状也会进一步加重[2]。要阻止甲状腺功能正常的HT患者出现不可逆转的甲减,临床常给予硒制剂、左甲状腺素钠、糖皮质激素及中药治疗[3]。本研究旨在观察小金胶囊( g/粒)联合硒酵母治疗甲状腺功能正常HT患者的疗效与安全性,现将结果报道如下。
1 资料与方法
一般资料 选取2016年6月至2018年6月我院内分泌科门诊及病房的甲状腺功能正常、中医辨证为气滞血瘀痰凝的的HT患者60例作为研究对象,按随机数字表法以分为观察组(n=32)和对照组(n=28)。观察组中男10例,女22例,年龄26~62岁,平均年龄(±)岁,病程3~12个月,平均病程(±)个月;对照组中男12例,女16例,年龄28~60岁,平均年龄(±)岁,病程3~12个月,平均病程(±0