文档介绍：小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床效果
[摘要] 目的 探討小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床效果及安全性。 方法 选择2015年1月~2018年1月宜昌市第一人民医院收治的238例上呼吸道感染伴热性惊厥患tween the two groups before and after treatment. The adverse reactions in the two groups were recorded and compared. Results The total effective rate of the treatment group was higher than the control group, the difference was statistically significant (P < ). The defervescence time, the fading time of coughing, the fading time of nasal obstruction and nasal discharge, fading time of convulsion and the cases of convulsion recurrence in the treatment group were significantly less than the control group, the differences were statistically significant (P < ). After treatment, the serum NSE, S-100β level of the two groups were significantly lower than before treatment, and these in the treatment group were significantly lower than the control group, the differences were statistically significant (P ). Conclusion Xiaoer Yanbian Granules is effective in the treatment of upper respiratory tract infection complicated with febrile convulsion. It can shorten the duration of clinical symptoms and improve the brain injury of children, it is safe and worthy of clinical application. [Key words] Upper respiratory tract infection; Febrile convulsion; Xiaoer Yanbian Granules; Efficacy; Safety
热性惊厥是一种婴幼儿时期常见的中枢神经系统功能异常疾病,大多由上呼吸道感染所致,临床主要表现为意识突然丧失、面肌或四肢肌强直、凝视或斜视、双眼球上翻、痉挛或不停抽动、口唇發紫、牙关紧闭、大小便失禁、口吐白沫等症状,具有起病急、严重程度高的特点[1-2]。热性惊厥在婴幼儿中的发病率达3%~4%,发作年龄在6个月~3岁,大多数在5岁后不再发作,男孩中的发病率高于女孩[3-4]。近年来,上呼吸道感染伴热性惊厥的发病率逐年增高,严重威胁着婴幼儿的身体健康[5]。因此,对上呼吸道感染伴热性惊厥患儿给予及时有效的治疗具有重要的临床意义。目前,临床治疗上呼吸道感染伴热性惊厥主要采用退热、抗感染、补液等对症治疗措施,疗效并不理想[6]。小儿咽扁颗粒是一种含有金银花、金果榄、牛黄、冰片、麦冬、桔梗、玄参、射干等中药成分的中成药制剂,具有消肿止痛、消散脓栓、缓解咳嗽的作用[7]。现代药理学研究表明,牛黄能够通过血脑屏障,具有抑制中枢和保护大脑的作用[8]。本研究探讨小儿咽扁颗粒治疗上呼吸道感染伴热性惊厥的临床疗效及安全性,现报道如下:
1 资料与方法
一般资料
选择2015年1月~2018年1月宜昌市第一人民医院收治的238例上呼吸道感染伴热性惊厥患儿作为研究对象。纳入标准:①符合《诸福棠实用儿科学》[9](第7版)中有关上呼吸道感染伴热性惊厥的诊断标准;②临床表现出发热、咳嗽、流涕、咽痛等症状;③体温>℃,发热1~2 d内出现惊厥;④年龄4个月~5岁。排除标准:①肺炎、支气管炎、过敏性