文档介绍：网络首发时间：2022-05-05 11:43:08
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生命的化学,
such as PD-1/PD-L1 antibodies can inactivate tumor cell checkpoint, unleash the anti-tumor immune responses
of cytotoxic T cells. The biggest advantage of immunotherapy over traditional therapies is the durability and
broad spectrum anticancer capability. Despite that tumor immunotherapy has been applied unprecedentedly for
the treatment of various cancer, tumor immunotherapy drugs, like other cancer drugs, are inevitably become
resistant in tumor due to intrinsic genetic and extrinsic environmental factors. Here we focus on recent
progresses of the drug resistance mechanisms in immune checkpoint therapy, promoting our understanding of
the immunotherapy theory and technique to overcome the drug resistance of checkpoint block inhibitors.
Key Words: immune therapy; immune checkpoint inhibitors; drug resistance mechanisms
收稿日期：2022-01-28
基金项目：国家自然科学基金项目(31871439)；深圳市科创委基础研究项目(JCYJ20190807161213744)
第一作者：E-mail: ******@
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肿瘤已成为人类健康的主要威胁之一，且我 免疫攻击来保护自己。适应性耐药在临床上可以