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撰写人：___________日 期：___________
以作为早期糖尿病肾病的诊断指标之一。
的发生发展。
、HbA一e、BMI、TGF一pl可能是DN的重要危险因素
关键词:转化生长因子一pl糖尿病肾病撷沙坦
Effect of Valsartan on serum transforming growth
factor-p 1 levels in early diabetic nephropathy patients Master degree candidate:Feng Ran
Supervisor:Professor Bai Ran
Vice一supervisor: Yao JunJie
Maj or:internal medicine(endocrinology)
AbstraCt Objective: Diabetic nephropathy is one common and specific diabetic microvascular complication, and also the major cause of disability and mortality for diabetics. Transforming growth factor一p1 (TGF一p1)is a unique cytokine which induced fibrosis. Renal expression of TGF一p 1 is especially abundance and its overexpression promotes cell proliferation and hypertr- ophy of renal tissue to stimulate extracellular matrix , TGF一p 1 plays an important role in pathogenesis of renal protection of Valsartan which is an angiotensin II (Ang II)receptor antagonist (ARB), has been confirmed. At present, there is no enough research about the
relationship between the level of serum TGF一p 1 and early DN, especially the period before microalbuminuria, as well as the effect of Valsartan on this phase of , the study was to analyze the serum TGF一p1 levels of patients with early DN, in order to find out the relationship between serum TGF一p 1 and early DN，and also to clarify whether Valsartan play a role in renal protection by reducing the level of serum TGF一p1.
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Methods:The present study included 69 patients who were suffering from type 2 diabetes and with no clinical evidence of vascular complication of the heart ,brain and other chronic renal disease. All patients with high blood pressure were, medicated oral Valsartan 80mg/d for 2 weeks. 69 patients