文档介绍：门冬胰岛素联合二甲双胍对妊娠期糖尿病患者妊娠结局的临床分析
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[摘要] 目的 探討门冬胰岛素联合二甲双胍治疗妊娠期糖尿病(GDM)的临床效果。 方法 便利677, , P<); before treatment, there was no statistically significant difference between the two groups of Cys C and HCY levels (t=, , P=, ); after treatment, the levels of Cys C and HCY in the observation group were (±) mg/L and (±) μmol/L, which were lower than those in the control group (±) mg/L and ( ±) μmol/L, the difference was statistically significant(t=, , P<); the incidence of adverse anti-pregnancy outcomes in the observation group was %, which was lower than % in the control group, and the difference was statistically significant (χ2=, P=). Conclusion Insulin aspart combined with metformin therapy can stabilize the blood glucose level of patients with GDM, reduce the levels of Cys C and HCY, and reduce adverse pregnancy outcomes. [Key words] Gestational diabetes; Insulin aspart; Metformin; Pregnancy outcome; Blood glucose level
妊娠期糖尿病(GDM)是指妊娠前无糖尿病,妊娠后首次发生糖尿病或糖耐量异常,若无法稳定血糖水平,易诱发羊水过多、高血压等一系列并发症,并增加早产风险[1-2]。目前,饮食及运动控制是改善GDM患者的基础疗法,但多数患者血糖控制不佳,仍需药物配合。胰岛素是临床常用药物,可提高体内葡萄糖摄取及利用,并抑制肝糖异生,降低机体血糖,但该病患者多伴随不同程度的胰岛素抵抗,使得单一用药效果欠佳[3]。二甲双胍属于胰岛素增敏剂,常用于2型糖尿病治疗中,降糖效果显著,但临床关于其在GDM患者中应用效果仍无诸多报道[4]。鉴于此,该研究便利选取2018年5月—2019年5月采用门冬胰岛素联合二甲双胍治疗的41例GDM患者作为研究对象,旨在分析联合用药对妊娠结局的