文档介绍：传统抗癫痫药与新型抗癫痫药在疗效上无显著差异
Kwan P, Brodie MJ. N Engl Med. 2000; 342:314-315
0%
10%
20%
30%
40%
50%
60%
70%
80%
Pa传统抗癫痫药与新型抗癫痫药在疗效上无显著差异
Kwan P, Brodie MJ. N Engl Med. 2000; 342:314-315
0%
10%
20%
30%
40%
50%
60%
70%
80%
Patients seizure free for ≥1 year
Traditional AED
(n=289)
New AED
(n=134)
Patients treated with 1 AED
P=NS
67%
69%
70%
10%
0%
Persistent
seizures
Seizure free
for≥1 year
Patients with epilepsy (n-525)
60%
50%
40%
30%
20%
Patients
63%
37%
289 were receiving an established drug (155 were receiving carbamazepine, 125 valproate sodium, 8 phenytoin, and 1 ethosuximide),
134 were taking one of the newer antiepileptic drugs (99 were receiving lamotrigine, 15 gabapentin, 7 oxcarbazepine, 9 tiagabine, 3 topiramate, and 1 vigabatrin).
传统抗癫痫药与新型抗癫痫药在疗效上无显著差异
N Engl J Med 2000;342:314-9.
470 patients has never received
An antiepileptic drug before
(64% seizure-free)
Epilepsy was not controlled by
1st antiepileptic drug in 248;
168 receved an established drug
and 80 received a new drug
69 Had intolerable
Side effects
(41% seizure-free)
29 Had an idiosyncratic reaction
(55% seizure-free)
37 Had other reasons
For stopping treatment
(62% seizure-free)
Figure 3. Outcome in 470 Previously Untreated Patients.
The status of patients at the time of the last clinic visit is given in parentheses.
Epilepsy was controlled by 1st antiepileptic
drug in 222 (47% seizure-free);
151 received an established drug (47% seizure-free)
and 71 received a new drug (47% seizure-free)
Treatment was
Ineffective in 113
(11% seizure-free)
总结
传统抗癫痫药物如丙戊酸钠、卡马西平、苯妥英钠仍旧是新诊断癫痫患者的首选单药治疗药物
除非新药在疗效、成本效益和生活质量上能显示出其优越性，否则他们仍将作为二线用药
Payakachat et al. J Manag Care Pharma 2019
谢谢聆听
2008年安全评价人员教育培训