文档介绍:: .
现代食品科技L/6雄性小鼠分成空白对照组(Normal diet,ND)、模型组(High-fat diet,HFD)、全蛋摄入组(High-fat diet+egg,
EGG)、去蛋黄替代物组(High-fat diet+substitute of free egg yolk,SUB)和洛伐他汀组(Lovastatin,Lov)。实验周期为60 d,末期测
定脏器指数、相关生化指标、组织切片及相关酶水平。结果显示,EGG摄入显著抑制小鼠体重增长(p<)。EGG血清中低密度脂
蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)和总胆固醇(total cholesterol,TC)%%。
较HFD组,EGG和SUB抑制了由HFD引起的肝脏中超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondialdehyde,MDA)
含量上升,%%,同时SUB组肝脏中TC和甘油三酯(serum triglyceride,
TG)最低, mmol/ mmol/L。EGG显著降低肝脏天冬氨酸转氨酶(aspartate transaminase,AST)和天冬氨酸转氨酶
/丙氨酸转氨酶(AST/ALT)比值(p<),%%。此外,EGG能显著抑制肝脏脂滴的形成和附睾脂肪细
胞增大(p<)。因此,较SUB,EGG能更好地调控MetS小鼠的血脂代谢。
关键词:全蛋;去蛋黄替代物;代谢综合征;小鼠;脂代谢
DOI: .1673-
Comparative Analysis of Effects of Whole Egg and Substitute of Egg Yolk
Consumption on Lipid Metabolism in Mice with Metabolic Syndrome
YU Zhihui, ZHOU Liyuan, ZHU Yingchun*
(Food Science School of Engineering, Shanxi Agricultural University, Taigu 030801, China)
Abstract: In order to study the effects of whole egg and substitute of egg yolk consumption on lipid metabolism in mice with metabolic
syndrome (MetS), a MetS mouse model was constructed through high-fat feeding in this experiment. Forty C57BL/6 male mice were divided
into control group (normal diet, ND), model group (high-fat diet, HFD), whole egg consumption group (high-fat diet+egg, EGG), substitute of
egg yolk consumption group (high-fat diet+substitute of free egg yolk, SUB) and lovastatin group (Lov). The organ index, biochem