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tochondriaextractedfromMCAOratstreatedbyQishenGranules.Westernblotwasusedtodetectchangesintheexpressionofun
couplingprotein(UCP)1andUCP2whichwascloselyassociatedwithbrainmitochondrialfunction.Results:QishenGranulesand
theirmainmedicinalcomponentscouldincreasethelevelsofaerobicrespirationofmitochondriaandimprovetherespiratoryfunc
tionofbrainmitochondriainratswithischemicstroke.Comparedwiththemodelgroup,theproteinexpressionofUCP1andUCP
2intheQishenGranulesgroupdecreased(P<001).Conclusion:QishenGranulescansignificantlyincreasethelevelofmito
chondrialenergymetabolismofnervecellsafterhypoxia,reducethedamageofbrainmitochondrialrespiratoryfunctioninratswith
ischemicstroke,andtheregulatoryeffectmaybecloselyrelatedtoUCP.
Keywords QishenGranules;PC12cells;Oxygenglucosedeprivation;Stroke;Energymetabolism;Mitochondrialrespiration
rate;Uncouplingprotein;Brainandhearttreatment
中图分类号:R2855 文献标识码:A doi:10.3969/j.issn.1673-7202.2022.07.013
芪参颗粒是基于慢性心力衰竭临床研究,以真 疗,如其对缺血性中风保护作用尚无相关报道。
武汤和四妙勇安汤为基础化裁而得,主治气虚血瘀 细胞能量代谢障碍是缺血性中风早期病理的标
所致的慢性心力衰竭证[1]。基于“虚、毒、瘀”的病