文档介绍:宁夏医学杂志 2022 年4 月第 44 卷第 4 期 Ninnig Med J, Apt. 2022, , Journal of Chronic
Obstructive Pulmonam Disease ,2019,14 : 163 - 162.
IL-8 mRNA表达水平增力□,但当miR -28a过表达和
[10] GORSKA K,NEJMAN-GRYZ P, PAPLIXSKA - GORYCA M,x
(或)BRD4表达被敲低时降低。结果表明miR-216p
al. Comparative stuUp of IL 一 33 and IL - 6 levels in dPereut rc-
可能通过靶向BRD4调节支气管上皮细胞中炎性细胞 spimWn samples in Milh - to - Moderate asthma and COPD [ J].
因子的表达,从而导致COPD的气道炎症° Journal of Chrodic Obstructive Pulmoxa. Disease: 2013,15(1):
综上所述,本研究显示COPD患者肺中miR - 36-452
[11] NAKAMOTO K, WATANABE M, SADA M,et al. PsexUomoxas
216a表达降低,并且miR-216p降低与肺功能和炎
aerupincna - delved flayellin stimulates IL - 6 and IL - 2 produc-
症有相关性;BRD4是miR-28a的靶点,在COPD