文档介绍：孕妇血清维生素A、维生素E、25-羟基维生素D与子痫前期的相关性研究
摘要:目的 探討孕妇血清维生素A、维生素E、25-羟基维生素D水平与子痫前期的相关性。方法 选择2016年3月~2017年10月在我院产检的单胎孕妇为研amin D levels were significantly correlated with pre-eclampsia at 24 to 28 weeks of pregnancy. Regression models showed that serum vitamin A was diagnosed with pre-eclampsia AUC. , 95% CI was ~, when the cutoff value was , the sensitivity of predicting pre-eclampsia was %, the specificity was %; the AUC of vitamin E diagnosis pre-eclampsia was , 95% CI was ~, when the cut-off value is , the sensitivity of predicting pre-eclampsia is %, the specificity is %; the AUC of 25-hydroxyvitamin D is pre-eclampsia is , 95% CI is ~, When the cut-off value is , the sensitivity of predicting pre-eclampsia is %, and the specificity is %. The serum A-vitamin A+vitamin E+25-hydroxyvitamin D is pre-eclampsia with an AUC of and 95% CI of ~ . When the cutoff value is , the sensitivity of predicting pre-eclampsia is %, and the specificity is %. Conclusion At the age of 10~14 weeks, the serum levels of vitamin A, vitamin E and 25-hydroxyvitamin D are not related to the pre-eclampsia. At the age of 24~28 weeks, serum vitamin A, vitamin E and 25-hydroxyvitamin D The level of decline is significantly associated with pre-eclampsia, and serum vitamin A, vitamin E, and 25-hydroxyvitamin D can be used as key indicators of pre-eclampsia in the third trimester. Key words:Pre-eclampsia;Vitamin A;Vitamin E;25-hydroxyvitamin D
子痫前期(pre-eclampsia,PE)是在妊娠20周后出现的以高血压、蛋白尿为特征的妊娠期特发性疾病。子痫前期可累及母体多个系统,并导致胎儿缺氧、生长发育受限,是导致孕产妇和围产儿死亡的主要原因之一[1]。近年来,随着我国“全面二孩”政策的放开,高龄孕产妇增多,子痫前期发病率呈逐年上升的趋势。子痫前期的病因和发病机制目前尚未完全阐明,可能涉及遗传易感性、免疫耐受失衡和炎症氧化应激等多種因素[2,3]。维生素A、维生素E、维生素D是人体代谢必不可少的脂溶性维生素,具有抗氧化和免疫调节等多种作用,其在子痫前期、妊娠期糖尿病等妊娠期并发症中的作用也受到越来越多的关注[4,5]。本研究通过检测孕妇血清中维生素A、维生素E、25-羟基维生素D的水平,分析其与子痫前期的相关性,旨在为子痫前期的早期诊断和治疗提供参考依据,现报告如下。
1资料与方法
选择2016年3月~2017年10月南方医科大学附属东莞人民医院接诊的72例子痫前期患者作