文档介绍：第 37 卷第 6 期 2022 年 6 月 现代药物与临床 Drugs & Clinic Vol. 37 No. 6 June 2022 ·1239·
UPLC-MS/Meaction monitoring scanning was
used for quantification with electrospray positive ions model. The ion source temperature was 150 ℃, the capillary voltage was
kV, the cone voltage was 50 V, the desolvation gas flow rate was 800 L/h, and the desolvation gas temperature was 400 ℃. Results
The linear ranges of protopine, palmatinechloride, dehydrocorydaline, tetrahydropalmatine, and corydaline were — ng,
— ng, — ng, — ng, and — ng, respectively. The average recoveries were %, %,
%, %, and % with RSD of %, %, %, %, and %, respectively. The contents of five alkaloids in
Corydalis yanhusuo from different origins were obviously different. The contents of five alkaloids in Corydalis Rhizoma from Zhejiang
Province origin were higher than those of other origins, and the content of dehydrocordine was the highest among the five alkaloids.
Conclusion The established method is easy, rapid, and accurate which can be used for the content determination of five alkaloids in
Corydalis Rhizoma
Key words: Corydalis Rhizoma; protopine; palmatinechloride; dehydrocorydaline; tetrahydropalmatine; corydaline; UPLC-MS/MS
延胡索为罂粟科植物延胡索