文档介绍：1 再生障碍性贫血患者骨髓肾素血管紧张素系统表达的研究作者:彭敏源,赵谢兰,高欣,雷瑚仪【摘要】肾素血管紧张素系统( RAS )已被证明参与了骨髓造血细胞的生长增殖和分化,而再生障碍性贫血( AA )被认为是与骨髓造血细胞受损和造血微环境缺陷有关的疾病。为了探讨 AA 的发病机制,运用放射免疫方法检测 22例 AA 患者骨髓和外周血肾素活性及 Ang Ⅰ、 Ang Ⅱ浓度,并以 16 例外周血常规和骨髓检查正常的患者为对照组, 比较两组之间的差异。结果发现: AA 组骨髓 Ang Ⅱ浓度低于对照组( ), AA 组的骨髓 Ang Ⅱ浓度与外周血比较差异无统计学意义( P> ) ,对照组的骨髓 Ang Ⅱ浓度较同组的外周血高( ) ,两组的肾素活性及 Ang Ⅰ浓度差异无统计学意义( )。结论: AA 患者骨髓 Ang Ⅱ浓度降低,AA 发病可能与其有关。【关键词】再生障碍性贫血 2 Renin Angiotensin System in Bone Marrow of Patients with Aplastic Anemia Abstract Renin-angiotensin system (RAS) has been shown to be involved in the growth , production , proliferation and differentiation of the bone marrow (BM) hematopoietic cells , while aplastic anemia (AA) isa disease in which proliferation ability of the BM hematopoietic cells is damaged with defective hematopoietic microenvironment. To investigated the pathogenesis of AA , the rennin activity , angiotensin Ⅰ(Ang Ⅰ) and angiotensin Ⅱ(Ang Ⅱ) concentration in peripheral blood and BM of 22 AA patients were detected by radioimmunnoassay , 16 nonhematological disease patients with nomal blood counts and BM picture were used as control , and the differeence between two groups pared. The results showed that BM Ang Ⅱ concentration in the AA patients was significantly lower than that in the control ( ). In nonhematological disease patients , Ang Ⅱ concentration in BM was significantly higher than that in peripheral blood , the renin activities and Ang Ⅰ concentrations were not significantly different in the two groups ( ). In conclusion , the decreased 3 BM Ang Ⅱ concentration in AA patients may be involved to the pathogenesis of AA. Key words aplastic anemia; rennin angiotensin system; Ang Ⅰ; Ang Ⅱ; bone marrow hematopoietic cell 肾素血管紧张素系统(renin-angiotensin system , RAS) 被认为是调节血压电解质的内分泌系统, 然而近年发现, 该系统在许多组织中( 心脏、血管、肾脏和消化系统) 存在旁分泌和自分泌, 并参与组织器官的损伤修复。 199 6年 Haznedarogl u 等[ 1 ]首次提出骨髓中也存在 RAS ,并认为该系统在病理和生理条件下对骨髓( BM )造血、造血细胞的生成和增殖分化可能产生作用。目前已有研究发现, 血管紧张素Ⅱ(Ang Ⅱ) 能够促进放射线损伤后小鼠骨髓造血功能的