文档介绍：1 多奈哌齐治疗阿尔茨海默病的临床疗效研究【摘要】目的: 验证多奈哌齐( Donepezil ) 治疗阿尔茨海默病(AD) 的安全性及有效性。方法:对 61例AD 患者进行多奈哌齐和他可林( Tacrine ) 的多中心开放、对照治疗, 其中多奈哌齐组 33例( 5mg/d ), 他可林组 28例(平均 100mg/d ) ;共治疗 12 周。应用简易精神状态检查( MMSE ) ,日常生活能力量表( ADL )评定临床疗效,用副反应量表( TESS ) 评定副反应。结果: 多奈哌齐组治疗总有效率为 % , 显效率为 % , 他可林组分别为 % 和 % , 起效时间均在治疗第四周末; 两组间差异无显著性(χ2 分别= 和 )。多奈哌齐组和他可林组治疗前后 MMSE 评分及加分率, ADL 评分及减分率的差异均无显著性( ) 。多奈哌齐组的不良反应较他可林组显著少而轻, 仅有 6 例病人存在轻度的恶心或胃纳减退。结论: 多奈哌齐能有效治疗 AD ,且不良反应少而轻微。【关键词】阿尔茨海默病;多奈哌齐;他可林 parative study of donepezil and AlzhEimer disease for 2 Clinical research 【 abstract 】 Objective Verify that the Donepezil of many what Pains cures safe nature and effectiveness that Ah you AlzhEImer disease ( AD ) .Methods But having more what the many centers open of neat and he forest ( Tacrine ) of Pay and contrast to 61 example AD patients is cured , among them many what I Zoos Pay 33 examples ( 5mg/d ), but his Lin Zu of 28 examples ( average 100mg/d ) We should cure 12 weeks altogether . Applying the simple and easy state of mind check ( MMSE ), the day-to-day viability scalogram ( ADL ) is passd judgment on the clinical curative effect , with the by-reaction scalogram ( TESS ) evaluation by-reaction . Results Many what Qi Zu Pai cure that but total availability for %,shis ponent part not for % is all curing the around end with %, rises to imitate time for %,s produce effects rate The difference does not have the significance (χ2 parts = and ) between two teams . But many what Qi Zu Pai and his Lin Zu MMSE around curing gives a mark and adds the divides rate, and ADL gives a mark to be reached difference that subtracts the divide rate all not to have the significance (). 3 But his Lin Zu is seldom notable and light to the many what bad reactions ofI Zu Pay, and the nauseating or stomach that only has 6 example patients gently to exist to spend is received to donepezilis an effective Treatment Medicine Alzheimer disease