文档介绍：Chapter 12. Epilepsy
THE FIRST AFFILIATED HOSPITAL, SUN YET-SEN UNIVERSITY
PROF. ZHOU LIE MIN
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Symptomatic . Congenital diseases Structural Lesion of the Brain:
Epilepsy . Brain trauma 1. Remarkable decrease in the
. Infection of CN synaptic from GABA.
. Brain tumor of blood-brain barrier
. Cerebrovascular D Biochemical Aspects: Decrease
. Degenrative D in synthetic GABA and increase
. Toxicosis in excitatory transmitter.
. Nutritive and Electrophysiological Aspects:
metabolic disturbance Paroxysmal depolarization
. The others shift (PDS) discovered
Atiology Pathogenesis
Primary epilepsy Inheritance Mutation in Ion Channel
(Idiopathic) (Usually no brain damage)
cryptogenic ep unclear cannot be discoveried
Mutation in Ion Channel
ADNFLE
The Elements of Interfering with Epilepsy
Inheritance: Be susceptible to epilepsy or epileptic
predisposition ( abnormal EEG)
Environmental Influences: Fatigue or hunger,
Hyperventilation
The Others: Age, Endocrinosis, Sleep Disturbance
(Dysfunction)
Part 2. ATIOLOGY AND BBASIC MECHANISMS OF
EPILEPTOGENESIS, THE INDUCING ELEMENTS
Part 2. BBASIC MECHANISMS OF EPILEPTOGENESIS
Inheritance or acquired factors
Abnormal gene expression
Neurotransmitter and modulator dysfunction
Structure and function disorder of Ion-channel
Neuronal discharge
Epileptic seizure or epilepsy
Part 3: Clinical Manifestations of Ep