文档介绍：1 结直肠癌术后早期应用奥沙利铂联合 5 作者:凌瑞,张洪伟,李纪鹏, 王为忠【关键词】结肠直肠肿瘤 Safety of postoperative application of bined with 5FU/ in patients with colorectal cancer 【 Abstract 】 AIM: To investigate the safety of early application of adjuvant chemotherapy, bined with 5FU/leucovorin, in patients with colorectal cancer after radical colorectomy. METHODS: Thirtysix patients with colorectal cancer were randomized into two study groups. The treatment group recEived adjuvant chemotherapy using bined with 5FU/leucovorin on the 4th day after colorectomy; while the control group did not recEIve adjuvant chemotherapy. The tolerances of chemotherapy, the impact on wound healing, and the change of IL2, sIL2R in serum were determined. RESULTS: The healing condition of wound showed no significant difference between two groups. Chemotherapy 2 induced nausea and vomiting was reported in small numbers of patients in the treatment group, but was well controlled after antiemetic therapy. Neutropenia was not reported either in treatment group or control group. In addition, both groups showed the same change of IL2 and sIL2R. CONCLUSION: Early application of adjuvant chemotherapy using bined with 5FU/leucovorin is beneficial to the patients with colorectal cancer who have underwent radical colorectomy. It has no influence on the patients healing ability and will not increase the incidence of subsequent symptoms after operation. Furthermore, adjuvant chemotherapy doesn ’t influence patients immune system and then will not reduce the body ’s antineoplastic ability. Futhermore, early application of adjuvant chemotherapy in patients after colorectomy can positively prolong the survival time and delay the recurrence. 【 Keywords 】 colorectal neoplasms; oxaliplatin; chemotherapy, adjuvant; timing 【摘要】目的: 对大肠癌术后早期应用奥沙利铂(乐沙定) 联合 5FU/ 甲酰四氢叶酸辅助化疗的安全性进行探讨. 方法:将 36 例行根治术的Ⅲ期大肠癌患者随机分为 3 2组, 治疗组于术后第 4 日开始应用奥沙利铂联合 5FU/ 甲酰四氢叶酸辅助化疗, 观察患者化疗反应情况、术后切口愈合状况和血清 IL2, sIL2 R 的变化, 对照组不做化疗. 结果:两组切口愈合状况无明显差异,化疗组有少数患者出现恶心、欲吐现象, 经对症处理后症状基本消失,