文档介绍：1 葛根素注射液对去卵巢大鼠雌激素样作用的研究【摘要】目的: 观察葛根素注射液对去卵巢大鼠血清雌二醇(E2) 水平的影响。方法: 大鼠 50只, 分为葛根素高剂量组、葛根素低剂量组、倍美力组、模型组、假手术组,每组 10 只。除假手术组外,均摘除大鼠卵巢造成去势模型。造模后第 7 天,检测大鼠血清 E2 水平,确定造模成功后, 相应予葛根素注射液、倍美力水溶液、生理盐水灌胃。各组用药后 30 天测血 E2 含量。结果:用药 30 天后,模型组大鼠血清 E2 水平明显低于其它四组,差异有显著性意义() 。结论:葛根素注射液可以提高去卵巢大鼠血清 E2 水平,具有雌激素样作用。【关键词】大鼠围绝经期葛根素注射液雌激素样作用 Abstract Objective:To investigate the effect of puerarin injection on serum estradiol in female rats with ovary :SD rats were divided to high 拟 dose puerarin 2 group, low 拟 dose puerarin group, premarin group, control group, and sham operation group, 10 rats in model was established in all groups except sham operation group (a essful model was identified by detecting the level of estradiol on the 7th postoperative day).The level of estradiol was determined on the 30th day after administration of puerarin injection, premarin solution, and saline, :The level of estradiol was significantly lower in the control pared to other 4 groups ().Conclusion:Puerarin injection has estrogen 拟 like effect by increasing the serum level of estradiol in ovariectomized rats. Key words rat perimenopause puerarin injection estrogen 拟 like effect 围绝经期综合征是指妇女在围绝经期过程中,由于卵巢功能衰退, 体内雌激素水平降低导致神经拟内分泌系统功能失调, 引起植物神经功能紊乱和精神神经症状等一系列临床症候群。雌激素替代疗法(ERT) 是目前临床上治疗妇女围绝经期综合征的经典方法。但长期使用雌激素可能增加乳腺癌及子宫内膜癌的风险, 即使与孕激素合用也不能完全消除这种危险[1] 。因此寻找一种理想的 ERT 药物,