文档介绍：1 双波长法研究注射用头孢匹***钠与甲硝唑注射液配伍稳定性[摘要] 目的探讨注射用头孢匹***钠与甲硝唑注射液临床配伍的稳定性。方法按临床两药配伍****惯,将头孢匹***钠与甲硝唑注射液按比例配制的待测溶液,于 20℃密闭放置 0、 、1、2、4h ,对其进行溶液外观、 pH 值和紫外吸收光谱检查, 并在波长 273nm 、 320nm 、 处,应用双波长紫外分光光度法同时测定头孢匹***钠与甲硝唑的含量。结果在 0~4 h 内,溶液外观、 pH 值和紫外吸收光谱基本不变化,头孢匹***钠与甲硝唑的含量没有明显的变化。结论注射用头孢匹***钠与甲硝唑注射液配伍在本次实验考察的范围内是稳定的。[关键词] 紫外分光光度法;注射用头孢匹***钠;甲硝唑注射液;配伍;稳定性 Stability study of bined metronidazole injection 2 [ Abstract ] Objective To explore patible stability of cefpiramide sodium with metronidazole At the room temperature ( 20℃) prepared solution of cefpiramide sodium in metronidazole injection was made by referring to the clinical prescription in standing-time 0, ,1,2,4 dual ultraviolet spectropotometry was design to study on the change of content patibility of metrinidazole and cefpiramide sodium and the change of patible liquid apparent an its pH were observed on absorption peak at 273 nm , 320 nm and The re were no evident changes in apparent , pH , content and absorption curves within 4 Cefiramide sodium patible with metronidazole injection in this experiment. [ Key words ] ultraviolet spectropotometry ; cefpiramide sodium;metronidazole injection ; compatible ; stability 头孢匹***钠与甲硝唑是两种作用完全不同的抗生素, 临床 3 上常将二者配伍用于许多感染性疾病的预防和治疗。头孢匹***钠是β- 内酰***类抗生素,具有β- 内酰***环的理化共性[1], 因而与其他药物配伍时, 应考虑配伍药物对其稳定性的影响。为了保证临床用药安全有效, 以及指导临床正确地配伍使用, 特对头孢匹***钠与甲硝唑注射液的配伍稳定性进行了研究,现总结