咪哒唑仑在新生儿胎粪吸入综合征机械通气中的镇静止痉效果观察.doc

文档介绍：1 咪哒唑仑在新生儿胎粪吸入综合征机械通气中的镇静止痉效果观察【摘要】目的: 对咪哒唑仑和***在新生儿胎粪吸入综合征( MAS ) 机械通气中的镇静止痉效果进行临床比效。方法: 回顾性分析临床上存在人机对抗、抽搐以致呼吸机参数下调困难、血氧饱和度不稳定而需用镇静药治疗的40 例 MAS 机械辅助通气患儿,根据镇静方法的不同分为治疗组和对照组各 20 例。两组患儿都使用苯巴比妥饱和量,治疗组加用咪哒唑仑, 首剂 ~ mg/(kg ·次), 后改为 ~ mg/ ( kg·h) 维持并逐渐减量至脱机, 对照组根据病情反复使用*** ~ mg/(kg ·次) ,比较两组的镇静止痉效果及安全性。结果:两组患儿上呼吸机辅助治疗 24h、 48h 的呼吸机参数及 3d 后心肌酶谱结果比较差异有统计学意义(P均 ), 治疗组优于对照组。结论: 苯巴比妥联合咪哒唑仑对 MAS 呼吸机辅助通气下的人机对抗、抽搐的镇静止痉效果优于苯巴比妥联合***,起效快,使用安全有效, 值得推广。【关键词】咪哒唑仑; ***; 新生儿; 胎粪吸入综合 2 征;机械通气[ Abstract ] Objective:To investigate the parison between midazolam and diazepam in adjunctive ventilation for neonates with meconium aspiration syndrome (MAS). Methods:Retrospective analysis was performed on 40 infants with MAS who had mechanical ventilation as an adjunctive treatment and then had man 拟 machine conflict, spasms leading to difficulties in turning down the parameters of the breathing machine, unstable oxygen saturation, which made the sedative treatment needed. These neonates were divided into the treatment group and the control group. Both groups used the phenobarbital up to its saturation with the treatment group having midazolam in addition, first dosage of ~ mg/kg, and then cut down to 拟 mg/(kg · h) till the machine taken off and the control group having ~ mg/kg of diazepam repeatedly and continuously according to the condition. The cura