文档介绍：1 鼻腔非霍奇金淋巴瘤的化学治疗及放射治疗作者:刘峰段云李菲杜技端【关键词】, 鼻肿瘤/ 药物疗法;鼻肿瘤/ 放射疗法;淋巴瘤, 非霍奇金/ 药物疗法; 淋巴瘤, 非霍奇金/ 放射疗法; 综合疗法;预后【摘要】目的:探讨不同治疗方法对鼻腔非霍奇金淋巴瘤( NHL ) 患者的预后影响。方法:在 59 例原发于鼻腔 NHL IE 期患者中, 化疗+放疗 33例, 放疗+化疗 8例, 单纯化疗 10 例,单纯放疗 8 例,化疗方案为 CHOP 。结果: 全组患者的 1,3,5 年生存率分别为 712% , 420% 和 385% , 不同治疗方法的生存率差异无显著性( P=03943 ), 但生存曲线显示, 放化组优于其他组。临床分期显示, IE 局限组患者 1,3,5 年生存率为 842% 、 677% 和 620% , IE 超腔组患者为 500% 、 143% 和 143% , 差异有显著性( P=00012 )。首程化疗≥3 个周期 24例, 首程放疗≥ 40Gy16 例, 完全缓解率( CR 率) 分别为 250% 和 750% ,差异无显著性( P=0002 ) 。首程化疗 2 2,3~4,5~6 个周期的 CR 率分别为 105% 、 250% 和 250% , 差异无显著性( P=048 ), 并发症发生率及治疗相关死亡率均以化放组为高( 394% , 152% ) ,但差异无显著性( P=0202 , P=0693 )。结论:I 期鼻腔 NHL 患者首选放疗, 以尽早达到局部控制, 再根据临床分期及恶性程度或国际预后指数( IPI ) 酌情给予更有效的化疗方案。【关键词】鼻肿瘤/ 药物疗法; 鼻肿瘤/ 放射疗法; 淋巴瘤, 非霍奇金/ 药物疗法;淋巴瘤,非霍奇金/ 放射疗法;综合疗法;预后【 ABSTRACT 】 Objective : To investigate the effects of different treatments on the prognosis of patients with nonHodgkins lymphomas in nasal cavity. Methods: A retrospective study on 59 patients who suffered from stage IE primary nonHodgkins lymphomas in nasal cavity was presented. The y were treated by radiotherapy and chemotherapy of CHOP regimen, in which 33patients recEived chemotherapy plus radiotherapy,8 patients received radiotherapy plus chemotherapy,10 patients received chemotherapy alone, and 8 patients received radiotherapy alone. Survival analysis was performed by KaplanMeier method, the difference between 3 groups was evaluated by logrank test, and parison of rates was carried out byχ2 test. Results: The total survival rates for 1,3 and 5year were 712%, 420% and 385% respectively. There was no significant difference among the patients received different treatments (χ 2=298,P=03943),but the patients received radiotherapy plus chemotherapy seemed to have a better survival rates than that of other patients. The 1, 3and5year survival rates were 842%, 677% and 620% for lesion limited in nasal cavity but were 500%, 143% and 143% for lesion extending into and involving in the adjacent structures (χ 2=1046, P=000