西酞普兰治疗儿童抑郁和情绪障碍临床研究_0.doc

文档介绍：1 西酞普兰治疗儿童抑郁和情绪障碍临床研究作者:郭华杨长虹郭平【关键词】儿童;抑郁;情绪障碍;西酞普兰【摘要】目的观察西酞普兰治疗儿童抑郁和情绪障碍的疗效及安全性。方法对 23 例儿童抑郁和情绪障碍患者给予西酞普兰治疗,初始剂量 10mgd-1,1w 后视病情逐渐增加剂量, 最高剂量≤ 50mgd-1 , 平均剂量 25± -1 , 疗程 8w 。对存在严重失眠症状者酌情使用苯二氮艹[] 卓类药物。于治疗前及治疗第 4、 8w 末采用艾氏儿童行为量表评定临床疗效, 副反应量表评定不良反应。艾氏儿童行为量表减分率≥ 60% 为有效,< 60% 为无效。以艾氏儿童行为量表< 5 分为临床痊愈。结果治疗第 4、 8w 末艾氏儿童行为量表评定总分、抑郁、焦虑、强迫因子分均较治疗前有显著下降, 差异有极显著性( P 均< ) 。常见不良反应有体重增加, 轻度胃肠道反应。结论西酞普兰治疗儿童抑郁和情绪障碍疗效显著,安全性高。 2 【关键词】儿童;抑郁;情绪障碍;西酞普兰 Clinical studies of citalopram in children with depression and emotional disorder 【 Abstract 】 Objective To explore the curative effects and safety of citalopram in children with depression and emotional disorder. Methods 23 children with depression and emotional disorder were treated with citalopram, initial dose was 10mg/d which gradually increased after one week, maximal ≤ 50mg/d and mean 25± for 8 weeks. The children who had severe insomnia were given benzodiazepines. Curative effects and adverse reactions were assessed with the Child Behavior Checklist(CBCL) and Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of 4th and 8th week of treatment, respectively. The scorereducing rate of the CBCL ≥ 60% was effective and 60% ineffective. The score of the CBCL 5 was clinical recovery. pared with pretreatment, the total score and scores of depression, anxiety pulsion significantly decreased at the ends of 4th