文档介绍：2017-6-9药物的多晶型研究药物的多晶型研究 2017-6-9提纲?什么是晶体,多晶型? ?多晶型研究对药物开发的重要性?如何筛选和选择药物的新晶型?多晶型的主要分析手段?晶型筛选实验的经验分享---- 溶剂选择 2017-6-9 Crystal A solid material whose constituent atoms,molecules, or ions are arranged in an orderly repeating pattern extending in all three spatial dimensions. Pharmaceutical crystals Most drugs are developed as crystalline ? Stability ? Processability ? IP protection 什么是晶体? 什么是多晶型? ? Polymorphism is the ability of a solid material to exist in more than one form or crystal structure. ? Polymorphs ? Sold phase ? Same position ? Different molecular arrangements ? In practice, we are interested in all the crystalline and amorphous phases for a chemical/pharmaceutical 2017-6-9 2017-6-9 2017-6-9 多晶型研究对药物开发的重要性 2017-6-9 药物多晶型研究的重要性 2017-6-9 2017-6-9 如何筛选和选择药物的新晶型