文档介绍：•临床研究・ Electronic Journal of Practical Gynecological Endocrinology 2022
DOI: was statistically significant
(P<). The incidence of adverse reactions was % in the study group and % in the control group, with no statistical
significance (P>). Conclusion Orlistat combined with metformin is effective in the treatment of obese patients with PCOS.
It can reduce their body weight and insulin resistance, improve their blood glucose level, and has high safety. It is worthy of clinical
promotion and application.
[Key words] Polycystic ovary syndrome; Obesity;Insulin resistance; Orlistat; Metformin
多囊卵巢综合征(polycystic ovarian 有关调查显示，PCOS女性中肥胖症占比高达
syndrome, PCOS)是处在青春期、育龄期女性 40%〜60%,且20%〜40%患者约在40岁发生糖耐
群体一类常见的内分泌疾病，主要表现为月经 量异常，甚至为2型糖尿病肥胖型PCOS患者
紊乱、高雄激素血症、持续性的排卵障碍、卵 多存在胰岛素抵抗现象，需采用降糖药物进行治
巢呈现多囊样改变等，会影响其生育能力。据 疗。二甲双肌具有降糖效果，可改善患者病情，
通信作者：张莉，E-mail： ******@
76实用妇科内分泌电子杂志 2022年第9卷第5期 .临床研究«
但效果仍不理想，无法同时控制患者的血糖水平 服屈螺***烘雌醇片（拜耳医药保健有限公司，国
与体质量闵。奥利司他属于一类减重药物，已被广 药准字J20130120,规格：每片含屈螺***3 mg与烘
泛用于肥胖症治疗，可降低患者脏器内的脂肪水