文档介绍：Chapter 8:DISEASES OF CARDIOVASCULAR SYSTEM
Department of Pathology
TJMC, HUST
Wang Guoping
Contents
Section 1 Atherosclerosis
Section 2 Coronary AS and CHD
Section 3 Hypertension
Section 4 Aneurysm
Section 5 Rheumatism
Section 6 Infective endocarditis
Section 7 Valvular Vitium of the heart
Section 8 Others
动脉粥样硬化 Atherosclerosis, AS
冠状动脉AS及冠心病 Coronary AS & CHD
高血压病 Hypertension
动脉瘤 Aneurysm
风湿病 Rheumatism
感染性心内膜炎 Infective Endocarditis
慢性心瓣膜病 Chronic valvular vitium
心肌病 Cardiomyopathy
心肌炎 Myocarditis、心包炎 Pericarditis
先天性心脏病 Congenital heart disease
ATHEROSCLEROSIS (AS)
Arteriosclerosis
hardening of the arteries
thickening and loss of elasticity
of arterial walls
three forms:
Atherosclerosis
Mönckeberg medial calcific sclerosis
Arteriolosclerosis
ATHEROSCLEROSIS (AS)
Characterized by:
Intimal lesions called atheroma, or atheromatous or fibrofatty plaques.
Characterized by:
2. They protrude into and obstruct vascular lumina, weaken the underlying media, and may undergo plications.
Characterized by:
3. AS affects
elastic arteries (aorta, carotid, and iliac arteries) and large and medium-sized muscular arteries (coronary and popliteal arteries)
ETIOLOGY & PATHOGENESIS
Risk Factors:
hyperlipidemia
hypertension
cigarette smoking
diabetes mellitus
hyperhomocystinemia
others: age, sex and ics
ETIOLOGY & PATHOGENESIS
2. Response to injury hypothesis: