文档介绍：恶性脑肿瘤的化学治疗
四川省肿瘤医院内科
张智慧
Cerebrum and Cerebellum
流行病学趋势
2005 (US) 18,500* 12,760
Incidence per 100,000 (annual rate)
Adjusted 5 yr survival rate (1995-2000)
33% adults
73% children
2nd leading cause of cancer deaths in persons < 39 years (US in 2002)
Jemal et al CA: a cancer journal for clinicians 55:10-30, 2005.
new cases deaths (estimated)
流行病学趋势
%的速度在增加
CNS原发肿瘤发病率
Brain Tumor Facts & Statistics
©2007 Brain Tumor Society
Five Year Survival Rates by Age Group
Age
Survival Rates
0 - 19 years
%
20 - 44 years
%
45 - 64 years
%
Over 65
%
Data From: 2002 - 2003 Primary Brain Tumors in the United States Statistical Report. Fact Sheet (197 3- 1999 data). Brain Tumor Registry of the United States
CNS原发肿瘤五年生存率
tsheet/.
转移性脑肿瘤
(Brain Metastases BM)
定义:S以外组织的肿瘤发生播散,累及脑组织
是成年人群最常见的颅内肿瘤,随全身肿瘤整体治疗水平提高和生存延长,脑转移瘤发生率不断上升,实体瘤患者15%-20%最终会发生脑转移。
Brain Tumor Facts & Statistics
不同肿瘤发生闹转移的比例
肺癌
乳腺癌
恶黑
大肠
肾
原发灶不明
小细胞非小细胞
50% 33% 20% 50% 5% 5% 15%
多发性多发性多发性单发单发混合
脑转移性肿瘤的发生率
Varies according to primary site
Lung - 18-64%
Breast - 2-21%
Colo-rectal - 2-12%
Melanoma - 4-16%
Renal - 1-8%
Thyroid - 1-10%
Prostate, skin, oropharyngeal - rarely
Overall incidence 6-24%