文档介绍：: .
辽宁中医药大能失常、MicroRNAs、肠道内环境紊乱等。临床中
旨在减轻高血糖状态、调节机体新陈代谢水平以及提供先进的科学诊疗手段，但随着新型降
糖药物及作用靶点的不断深入研究，目前仍不能发现 2 型糖尿病发生及发展的有效且关键的
切入点，因此深入研究胰岛素抵抗的发病机理，从多个研究方向出发则成为当今破解 2 型糖
尿病难题的关键，该方法可为 2 型糖尿病的多靶向治疗或综合整体治疗提供明确的思路和方
向，为 2 型糖尿病的基础研究及临床诊疗提供新的思路。本文归纳和总结了胰岛素抵抗研究
的最新进展，并进行了深入分析，进一步明晰了胰岛素抵抗产生的原因和多重发病机制，明
确了微观调控代谢平衡及防治胰岛素抵抗的作用机制，结合多靶向新药开发从而制定出了宏
观与微观的控糖策略，为 2 型糖尿病整体综合治疗策略的制定提供更多的理论依据。
关键词：胰岛素抵抗；病理机制；靶点治疗；胰岛素分泌
Analysis of the mechanism and factors of IR in T2DM and its prevention and
treatment strategy
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MENG Fan-shuo , WANG Xiao-yun , QI Feng , TIAN Chun-yu , LI Ji-an *
（1. North China University of Science and Technology, Hebei Key Laboratory of Integrated
Traditional Chinese and Western Medicine for Prevention and Treatment of Diabetes and Its
Complications, Hebei Tangshan 063210；2. Cangzhou Hospital of Integrated Traditional
Chinese and Western Medicine, Hebei Province, Hebei Cangzhou 061000)
Abstract：Insulin resistance as a key pathological basis for the development and progression
of type 2 diabetes, its etiology and pathogenesis is complex, the main pathological mechanism
including multiple aspects of insulin receptor pre-receptor, receptor binding and abnormal
molecular transduction functions, the main factors involved in a variety of cytokines,
基金项目：科技部对发