文档介绍：复脑汤在脑缺血再灌注损伤中的神经保护作用及其机制
作者: 刘素蓉,王敏,吴喜利,高艳琼
【关键词】再灌注损伤;超氧化物歧化酶;肿瘤坏死因子
【Abstract】 AIM: To investigate the neuroprotective mechanism of Funao decoction in the treatment of repeated cerebral ischemia/reperfusion injury. METHODS: Totally 70 mice ly divided into 7 groups of 10 mice each: blank control group, sham operated groups of 1 and 10 d, model groups of 1 and 10 d, herb groups of 1 and 10 d (Funao decoction). The mice in the herb groups ia/reperfusion 5 d later. One or 10 d after operation, the brains easure the activity of superoxide dismutase (SOD) and the contents of malondialdehyde (MDA), tumor necrosis factorα(TNFα) and interleukin1β(IL1β). RESULTS: The activities of SOD g/g and (±) mg/g respectively at 1 and 10 d after cerebral ischemia/reperfusion, as pared g/g]; odel group, Funao decoction g/g, F=, Q=, P<] and decrease the contents of MDA (F=, Q=,P<). Funao decoction played a doia/reperfusion injury through reducing the oxidation and dog/g相比,模型组鼠脑缺血再灌注后SOD活性第1日(±) mg/g和第10日(±) mg/g明显降低,MDA,TNFα,IL1β含量显著升高. 与模型组相比,复脑汤能显著提高SOD[(±) mg/g]的活性(F=,q=,P<),并降低MDA的水平(F=, q=,P<). 复脑汤组能显著下调小鼠大脑皮质TNFα(F=,q=,P<)和IL1β(F=, q=,P<)的水平. 结论: 复脑汤通过降低脑缺血再灌注后脑氧化反应以及TNFα和IL1β表达而起到神经保护作用.
【关键词】再灌注损伤;超氧化物歧化酶;肿瘤坏死因子α;白细胞介素1β
血管性痴呆(vascular dementia, VD)