文档介绍：碘缺乏和碘过量对大鼠心肌组织结构和电活动的影响
作者: 刘桂芝,张朝,吴逸明,叶振坤,陈祖培,阎玉芹【关键词】碘;甲状腺功能减退症;心电图;组织学
Effects of iodine deficiency and iodine excess on rat myocardial histology and electrical activity
【Abstract】 AIM: To observe the effects of iodine deficiency and iodine excess on rat myocardial histology and electrical activity. METHODS: Niy inistration, the median of urinary iodine easured. At 6 months after iodine administration, the level of thyroid hormone (TH) in serum easured by means of chemoluminescence. The electrocardiogram (ECG), the heart yocardium icroscope. RESULTS: As pared edian of urinary iodine and the level of serum TH eter of left ventricular cavity, the decreased thickness of left ventricular free ent, the level of urinary iodine rose significantly TH ent group, there TH among HI groups. The levels of TT3 declined in 10HI [(±) nmol/L], 50HI [(±) nmol/L] and 100HI [(±) nmol/L] groups pared ol/L] group (P<, P< and P<, respectively). The levels of TT4 ol/L] and 50HI [(±) nmol/L] groups pared ol/L] (P<). In addition, ong any HI groups (P>). Only in 5HI and 100HI groups, local myocardial fibrosis of left ventricle in normal rats and affect their myocardial histology and electrical activity.
【Key; electrocardiogram; histology
【摘要】目的:观察长期碘缺乏和碘过量对大鼠心肌组织结构和电活动的影响. 方法:90只o. 测定大鼠尿碘中位数,血清甲状腺激素(TH)水平,记录大鼠心电图,心脏脏器指数,光镜下观