文档介绍：Comparative Study on the Effect of Cerebralcare Granule and Its Disassembled Prescriptions on SHRs
Reporter: Qu Zhuo
Advisor: Prof. Gao Wenyuan
Cerebralcare Granule(养血清脑颗粒), one of the famous classical recipes in traditional Chinese medicin, is developed from the "Decoction of Four Drugs". It is able to ameliorate the detrimental effect on cognition following chronic cerebral hypoperfusion , improve cerebromeningeal microcirculation, inhibit platelet aggregation, and release vasospasm. Currently, the recipe is mostly used for treating headache, including migraine headache, neurogenic headache, etc.
源自经典现代改良
当归、川芎
芍药、熟地黄
延胡索、鸡血藤、夏枯草、决明子、珍珠母、钩藤、细辛
Introduction
Introduction
Primary hypertension:95%, Etiology is not clear
Secondary hypertension :5%, There is a clear and independent etiology
Hypertension(高血压) is a cardiovascular disease with the most epidemiological impact in the world and also represents a major risk factor for developing other diseases as endothelial dysfunction, metabolic syndrome, diabetes, renal dysfunction, congestive heart failure, coronary artery disease and stroke.
Worldwide hypertension is estimated to cause million premature deaths and % of the disease burden.
Research progress of Cerebralcare Granule
Mechanism of hypertension
1
2
Review
position analysis of Cerebralcare Granule
1
2
Experiment
Contents
Vasorelaxant effects of Cerebralcare Granule
#
5
Review 1
具有养血平肝、活血通络的功效;
用于治疗血虚肝亢所致的头痛,眩晕眼花,心烦易怒,失眠多梦。
养血清脑颗粒能够改善脑组织微循环;缓解血管痉挛,目前为治疗头痛、脑供血不足、高血压、眩晕、失眠等疾病的中药特效药。
--Research progress of Cerebralcare Granule
#
平肝药
珍珠母、
钩藤
散寒解表药
细辛
补血药
当归、白芍、
熟地
清热药
夏枯草、决明子
活血药
川芎、鸡血藤、延胡索
%
%
%
%
%
测定阿魏酸和芍药苷的含量较全面地反映和控制养血清脑颗粒的质量. 养血清脑颗粒中芍药苷和阿魏酸含量分别为
±,± mg/g.
定量分析
高展,等. 血清脑颗粒质量标准研究. 广东药学院学报. 2011,27(5): 484-488.
李文博,等. SPE-UPLC 法测定养血清脑颗粒中的芍药苷含量. 药物分析杂志. 2011,31(7): 1385-1388.
秦昉,等. 液相色谱-质谱联用测定养血清脑颗粒中芍药苷的含量. 中国医院药学杂志. 2007, 27(10): 1396-1398.