文档介绍：直肠癌术前淋巴化疗安全性分析
作者:孟强孟荣贵崔龙凌光烈刘冰
【摘要】目的研究直肠癌患者术前淋巴化疗应用的安全性。方法观察淋巴化疗后局部和全身症状、心肝肾及造血功能变化、术后吻合口愈合情况以及检测淋巴化疗前30 min和淋巴化疗后48 h血CD3+、CD4+、CD8+、CD4+/CD8+、CD(16+56)+。结果淋巴化疗对局部和全身症状、心肝肾及造血功能、术后吻合口愈合无明显影响;比较淋巴化疗前30 min与淋巴化疗后48 h,CD4+/CD8+升高(t=,P<),CD3+、CD4+、CD8+、CD(16+56)+无明显变化(t=,,,,P&gt;)。结论淋巴化疗具有安全性,短期内对机体免疫有一定促进作用。
【关键词】直肠肿瘤; 淋巴化疗
Clinical safety of preoperative lymphatic chemotherapy in the treatment of rectal cancer
【Abstract】 Objective To investigate the clinical safety of preoperative lymphatic chemotherapy in the treatment of rectal cancer. Methods The regional and systemic symptoms, postoperative stoma healing, haematogenesis, functions of heart, liver and kidney after lymphatic chemotherapy, and the level of CD3+, CD4+, CD8+, CD4+/CD8+, CD(16+56)+ in blood 30 minutes before and 48 hours after lymphatic chemotherapy phatic chemotherapy on the regional and systemic symptoms, postoperative stoma healing, haematogenesis and the functions of heart, liver and kidney. The level of CD4+/CD8+ 48 hours after lymphatic chemotherapy inutes before lymphatic chemotherapy. ConclusionsPreoperative lymphatic chemotherapy is safe and can enhance patients′ immunity in early stage.
【Key phatic chemotherapy
研究证明直肠癌术前淋巴结转移状态对淋巴化疗药物聚集浓度无明显影响[1]。但其安全性,特别是对吻合口愈合、机体免疫功能和全身重要脏器功能的影响,是临床工作者关心的重要问题。本研究旨在考察淋巴化疗的安全性。
1 资料和方法
临床资料
选择我科2006年12月至2007年8月进行手术治