文档介绍：西酞普兰治疗儿童抑郁和情绪障碍临床研究
作者:郭华杨长虹郭平【关键词】儿童;抑郁;情绪障碍;西酞普兰
【摘要】目的观察西酞普兰治疗儿童抑郁和情绪障碍的疗效及安全性。方法对23例儿童抑郁和情绪障碍患者给予西酞普兰治疗,初始剂量10mg・d-1,1g・d-1,平均剂量25±・d-1,疗程8 in children otional disorder
【Abstract】 Objective To explore the curative effects and safety of citalopram in children otional disorder. Methods 23 children otional disorder , initial dose g/d aximal ≤ 50mg/d and mean 25± for 8 nia ent Emergent Symptom Scale(TESS) before treatment and at the ends of 4th and 8th ent, respectively. The scorereducing rate of the CBCL ≥ 60% ent, the total score and scores of depression, anxiety and pulsion significantly decreased at the ends of 4th and 8th ost significant( all P<). Main adverse reactions ild gastrointestinal reactions. Conclusion Citalopram has notable curative effect and high safety in children otional disorder.
【Keyotional disorder; citalopram
西酞普兰是选择性5羟色胺(5HT)再摄取抑制剂(SSRIs)中对5HT选择性最强的一种新型抗抑郁药物[1],临床应用效果较为肯定,且副作用小[2~6],但应用于儿童的报告较少。本研究应用西酞普兰对儿童抑郁和情绪障碍进行治疗观察,现将结果报告如下。
1 对象与方法
对象随机选取河南省驻马店市精神病医院住院的23例儿童抑郁和情绪障碍患者为研究对象。入组标准:(1)符合《中国精神障碍分类与诊断标准》MD3)情感障碍的单次发作或反复发作抑郁症、双向情感障碍抑郁相,或特发于儿童和青少年时期的情绪障碍的诊断标准;(2)艾氏儿童行为量表(CBCL)[7]评分≥40分,其中抑郁、焦虑和强迫得分超过常模标准;(3)性别不限,年龄<18a。排除标准:(1)有严重自杀企图或自杀行为者;(2)需合并电痉挛或其它抗抑郁药治疗者;(3)有严重药物过敏史、严重躯体疾病、癫痫及正在服用单胺氧化酶抑制剂者。22例完成8o;情绪障碍13例,男7例,女6例,±,±。联用苯二氮艹[]卓类药3例,时间≤1g&#12539;d-1,早饭后口服,1g&#12539