文档介绍：柴葛清热颗粒成型工艺的研究
谭娟1,宋金春2,曾俊芬3 (1武汉大学药学院,武汉市 430072 2,3武汉大学人民医院药学部武汉市 430060)
摘要: 目的筛选出最佳的柴葛清热颗粒的成型工艺条件。方法:采用正交试验,以颗粒的粗粒与细粉总和的百分率为指标,综合评价柴葛清热颗粒成型工艺。结果:最佳工艺条件是干浸膏粉与糊精为1:,以90%乙醇制软材,60℃干燥,其颗粒的各指标均最好。结论: 柴葛清热颗粒制粒工艺条件的筛选为该产品的工业生产提供了科学理论依据。
关键词:柴葛清热颗粒剂;正交试验;成型工艺
Preparation Technology of Chaige Antiyretic Granules
TAN Juan, SONG Jing-chun, ZENG Jun-fen ( of Phamacy ,Wuhan University,wuhan 430072 2,3. Pharmacy Department,People Hospital of Wuhan University ,wuhan 430060)
ABSTRACT:OBJECTIVE To select a best preparation technology of gross chaige Antiyretic Granules. METHODS:According to total percentage of coarse granule and powder,orthogonal design was applied to prehensively the processing the granules. RESULTS The optimum process was: when The ratio of the extracted powder and dextrin was 1:,the moistening agent was 90% and the drying temperature was 60℃,the chaige Antiyretic granule preparation technology targets had better exhibition .CONCLUSION the optimized preparation technology of chaige provides scientific evidence for control of the technical manufacture
KEY WORDS: chaige Antiyretic preparation technology Orthogonal Test
柴葛清热颗粒系在明代陶华首创《伤寒论》的柴葛解肌汤的基础方下进行加减,由柴胡,葛根,白芍等组成。作为辛凉解表药,主治外感风寒表实,郁而化热之证。其中柴胡解表退热,疏肝解郁,升举阳气;葛根解肌清热为表药俩者共为君药;为了进一步发挥其疗效,克服传统汤剂的弊端,使用方便和减少服用剂量
,将其制成颗粒剂。本颗粒剂采用干浸膏粉配料,因中药提取粉吸湿性大,所以选择合适的辅料来制备颗粒剂对保证产品的质量和稳定性就尤为重要,所以本文对柴葛清热颗粒的制备工艺和辅料进行