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Diseaseof hematopoieticsystem
infantileanemia
(1)nutritionalirondeficiencyanemia(IDA)
(2)nutritionalmegaloblasticanemia
Primary/immunitythrombocytopeniaPurpura(ITP)
Leukemia
Embryostage
Mesoblastichaematogenesis:3wsbegin,8wsweaken,12-15wsdisappears。
liver:8wsbegin,6monthsgraduallyweaken,erythroblast、granularcellandmegakaryocyte.
Embryostage
3、spleen:12wsbeginerythrocyte,granule,
lymphocyte
4、Haematogenesisoflymphaticorgan
::11ws
Embryostage
5、myelo-haematopoiesis:6mons
Haematogenesisfunctionemphasis,makevariouskindsofbloodcells,uniquehematogenicorganafterbirth.
Haematopoiesispostnatal
1、marrow:
2、extramedullary:whenrequirementofhaemopoiesisincrease,liver、spleen、lymphadenectasis,hepatomegalyandsplenomegaly,incirculatingblood
immatureerythrocytesandgranulocytes.
Physiologicalhaemolysis
Normalnewbornshavehigherhemoglobin(HB)andhematocritlevelsandashortenedsurvivalperiodofthefetalRBCscontributes tothedevelopmentofphysiologicanemia.
Physiologicalhaemolysis
erythropoiesisabruptlyceaseswithonsetofrespirationatbirth,whenthearterialoxygensaturationrisestoward95%.levelsoferythropoietin(EPO)arelow.
EPOhasadecreasedhalf-.
thesizableexpansionofbloodvolumethataccompaniesrapidweightgainduringthefirst3mooflifeaddstotheneedforincreasedRBCproduction.
Redbloodcell(RBC)
Termnewbornshavearedcellmassthatishigherthanatanyothertimeoflife.
anappropriateconditionforthelowoxygenenvironmentofintrauterinelife.
×1012~×1012,hemoglobinconcentrationisabout150~220g/Latbirth.
TheRBCandhemoglobinconcentrationinpreterminfantsareslightlylowerthanthoseinterminfants.
Redbloodcell(RBC)
Thewiderangeofhemoglobinconcentrationisaccountedforby:
Variationinhowrapidlytheumbilicalcordisclamped.
Aninfant’spositionafterdelivery.
Ifcordclampingisdelayedandthebabyisheldlowerthanplacenta,bothhemoglobinandbloodvolumeareincreasedbyaplacentaltransfusion.