文档介绍：Hindawi Publishing Corporation
Stem Cells International
Volume 2012, Article ID 365932, 8 pages
doi:
Review Article
Cell Reprogramming, IPS Limitations, and ing
Strategies in Dental Bioengineering
Gaskon Ibarretxe, Antonia Alvarez, Maria-Luz Canavate,˜ Enrique Hilario,
Maitane Aurrekoetxea, and Fernando Unda
Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country (UPV/EHU), 48940
Leioa, Spain
Correspondence should be addressed to Fernando Unda, fernando.******@
Received 5 January 2012; Accepted 29 March 2012
Academic Editor: Paul Verma
Copyright © 2012 Gaskon Ibarretxe et al. This is an open access article distributed under the mons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to
revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The
potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to
precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on
IPS cells advises that research on their regenerative properties is carried out in appropriate tissue an systems that permit
a safe assessment of the long-term behavior of these reprogrammed cells. In the present paper, we discuss the mechanisms of cell
reprogramming, current technical limitations of IPS cells for their use in human tissue engineering, and possibilities to e
them in the particular case of dental regeneration.
1. Cell Dedifferentiation and Pluripotency environment. However, there are also significant problems
associated with the use of human ES cells.
Cellula