文档介绍：The progress of research with antitumor drug
[abstract]: Nearly 50 years of research and development of anticancer drugs has made considerable progress in cancer chemotherapy,particularly it enables patients with hematologic malignancies significantly prolong survival time,But a serious threat to human life and health accounted for over 90% of malignant solid tumors has not yet reached a satisfactory of cancer patients are still no response or resistance to treatment and eventually lead to treatment failure , so the discovery and development of new anticancer drugs by panies is still very difficult to be faced with the challenge of long-term mission[1].This chapter provides some brief about hot areas and the latest developments .
[keyword]:Antineoplastic,Traditional anticancer drugs , New anticancer drugs
anticancer drugs
Classification: According to the chemical structure and sources of drugs it includes alkylating antineoplastic agents(Cyclophosphamide), Antimetabolite
(Fluorouracil),Antibiotics ( doxorubicin .etc. ) , plant alkaloids ( vincristine ) , hormones .
Cytotoxic anticancer mechanism of action:①Interfering nucleic acid biosynthesis ② the drug that directly affects the DNA structure and function ③the drug that interferes with the process of transcription and RNA synthesis ④ the drug that interferes with protein synthesis and fu