病毒性心肌炎患儿心肌损伤标志物检测分析.doc

文档介绍：病毒性心肌炎患儿心肌损伤标志物检测分析
【摘要】目的:探讨联合检测心肌损伤标志物对病毒性心肌炎(VMC)患儿心肌损伤的诊断价值。方法:对52例VMC、58例非病毒性心肌炎(NVMC)患儿和50例健康对照者,分别检测血清3种心肌损伤标志物〔心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶MB质量(CKMB mass)、肌红蛋白(MYO)〕浓度和4种心肌酶活性。结果:入院当日VMC组cTnI(±)μg/L、CKMB mass(±)μg/L、MYO(±)μg/L,均明显比NVMC组和对照组高();联合检测cTnI、CKMB mass和MYO对VMC心肌损伤的诊断灵敏度(SE)、特异性(SP)、阳性预报值(PPV)、阴性预报值(NPV)和准确度(AC)%、%、%、%%;SE和NPV与联合检测4种心肌酶相近(P>),而SP、PPV和AC却明显比联合检测4种心肌酶高()。结论:联合并动态检测3种心肌损伤标志物比联合检测4种心肌酶能够为VMC心肌损伤的诊断、治疗和预后转归判断提供更好的诊断方法。
【关键词】病毒性心肌炎;心肌肌钙蛋白I;肌酸激酶同工酶MB质量;肌红蛋白;心肌酶

〔Abstract〕Objective:To study the diagnostic value of myocardial damage in children yocarditis by bined detection of cardiac markers. Methods: The concentrations of 3 kinds of cardiac markers of cardiac troponin I (cTnI), creatine kinase isoenzyme MB mass (CKMB mass), myoglobin (MYO) and 4 kinds of myocardial enzymes in 52 patients yocarditis (VMC) and 58 patients yocarditis (NVMC) and 50 healthy children ass and MYO pared ass and MYO in VMC group ination of cTnI, CKMB mass and MYO for myocardial damage in VMC patients arkers and bined measurement of 4 kinds of myocardial enzymes (P>). Hoarkers yocardial enzymes (). Conclusions: bined and continued detection of 3 kinds of cardiac markers can provide better information for diagnosis, treatment and recovery than bined test on 4 myocardial enzymes for myocardi