文档介绍：Regulation of Actin Dynamics
Integrin GPCR
RTK
Receptor
Sema1a
PlexinA
PI3K PLCγ PIP2
Gi
PI3K Gq
Src Grb2 Nck Gs
G13
FAK PIP 2+
Paxillin 3 Ca
F-actin Mical CaM PKCα
Bundles/ PLCβ
Meshworks NADPH Grb2
PAK1 WASP
Fascin
PIP PI3Kα
NADP 3
Severed GEF Filopodia
Filaments Ena
p130 GIT1/2 Ras PKA
VASP
PI3K PIP3
PI3K
PIX
Cofilin MEKK RhoGEF
TIAM1
PIX Vav
MEKK
Degradation Crk
Rac cdc42 PAK1 MEK Rho
Cortactin PAK1
mDIA
ROCK Filamin
WAVE WASP ROCK
PI5K
MLCK
MBS
Arp2/3 Ca2+
PIP IP3 CaM
2 LIMK MLCK mDIA Arp2/3 Filamin
PKD1 Profilin
14-3-3ζ
Calcineurin SSH MLC
CIN Cofilin ADF Filopodia Lamellipodia
Barbed-end
CapZ Cappers
Gelsolin Hsp90
Pointed-end
Tmod Cappers
Actin
Lamellipodia Polymerization Stress Fibers
Tropomyosins
© 2008 – 2010 Cell Signaling Technology, Inc. Regulation of Actin Dynamics • created September 2008 • revised November 2010
Signaling Pathways Key
Direct Stimulatory Modification
Kinase
Direct Inhibitory Modification
Phosphatase
Multistep Stimulatory Modification
Transcription Factor
Multistep Inhibitory Modification
Caspase
Tentative Stimulatory Modification
Receptor Tentative Inhibitory Modification
Enzyme Transcriptional Stimulation
Transcriptional Inhibition
Cyclin, pro-apoptotic
Translocation
pro-survival
Separation of Subunits or Cleavage Products
GAP / GEF
Joining of Subunits
GTPase
G-protein, ribosomal subunit
Acetylase
Deacetylase
© 2003 - 2010 Cell Signaling Technology, Inc.