文档介绍：该【Ultrasonic humidifier lung as a mimic of COVID ‐19 2021 Shosei Ro 】是由【tiros009】上传分享，文档一共【3】页，该文档可以免费在线阅读，需要了解更多关于【Ultrasonic humidifier lung as a mimic of COVID ‐19 2021 Shosei Ro 】的内容，可以使用淘豆网的站内搜索功能，选择自己适合的文档，以下文字是截取该文章内的部分文字，如需要获得完整电子版，请下载此文档到您的设备，方便您编辑和打印。OfficialCaseReportsJournaloftheAsianPacificSocietyofRespirology
RespirologyCaseReports
UltrasonichumidifierlungasamimicofCOVID-19
ShoseiRo,RyosukeImai,AtsushiKitamura,TorahikoJinta&NaokiNishimura
DepartmentofPulmonaryMedicine,ThoracicCenter,’sInternationalHospital,Chuo-ku,Japan.
KeywordsAbstract
Chestcomputedtomography,COVID-19,ultrasonic
(CT)hasbeenusedtocomplementcoronavi-
rusdisease2019(COVID-19),
CorrespondenceowingtothelowspecificityofCTfindings,differentialdiagnosisisessential.
RyosukeImai,DepartmentofPulmonaryMedicine,ThetypicalCTfindingsofCOVID-19includeground-glassopacifications
ThoracicCenter,’sInternationalHospital,andconsolidationswithpredominantdistributioninbilateral,peripheral,
9-1Akashi-cho,Chuo-ku,Tokyo104-8560,-specific
E-mail:******@
andmayresembleotherlungconditions,includingultrasonichumidifier
Received:1March2021;Revised:10April2021;lung,whichisaconditionthatdevelopsoninhalingaerosolsgeneratedby
Accepted:12April2021;AssociateEditor:-
--
solidationswithupperlobe-predominantdistribution,althoughatypicalfor
RespirologyCaseReports,9(6),2021,e00761COVID-19,,ultra-
sonichumidifierlungcouldbeadifferentialdiagnosisforCOVID-19indry
doi:
-
fierusearecriticaltothefinaldiagnosis.
bloodcellcount(WBC),lactatedehydrogenase(LDH),
Severeacuterespiratorysyndromecoronavirus2(SARS-
C-reactiveprotein(CRP),andKrebsvondenLungen-6
CoV-2)polymerasechainreaction(PCR)testingisconsid-
μ
eredthegoldstandardinthediagnosisofcoronavirusdis-(KL-6)levelswere10,200/L,366U/L,,and
ease2019(COVID-19),andchestcomputedtomography416U/mL,
fi
(CT)hasbeenusedtocomplementthismodalityduringwithbilateraldiffuseground-glassopacications(GGO)
,variousotherlungdiseasescouldandconsolidationsinthedorsalareasofbothlungs
mimictheCTfindingsofCOVID-19,makingdifferential().WeinitiallysuspectedCOVID-
diagnosisessential[1].Toourknowledge,thereisnosevererespiratoryfailure,methylprednisolone(1000mg/
reportondifferentiatingultrasonichumidifierlungfromdayforthreedays)forlunginjuryandempiricpiperacillin
COVID-()forsuspectedlunginfection
initiallysuspectedofCOVID-19infectionbutwerediag--
nosedwithultrasonichumidifierlungwithcharacteristicever,repeatedPCRandbloodandsputumculturesshowed
withupperlobe-
changingitswaterorcleaningthetanksforamonth
Case1lesionsonchestradiographsimprovedwithinthreedays.
A64-year-oldmanpresentedtoourhospitalwithafour-Basedonthischaracteristichistoryandhospitalcourse,we
levelof88%wasobtainedwiththeoxygenmaskat10L/patient’sconditionandtheCTfindingsresolvedon
,andmechanicalventilationwasavoidinghumidifieruseafterdischarge.
©&SonsAustralia,Ltd2021|||e00761
ThisisanopenaccessarticleunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsuse,distributionandreproductioninanymedium,providedthe
originalworkisproperlycited.
HumidifierlungmimicsCOVID-.
(CT)incase1showedcentrilobularparticles(seearrows).Consolidationswereseenonbothlungs’dorsal
area,whichwassimilartothosefoundincoronavirusdisease2019(COVID-19).
(CT)incase2showedperipheralconsolidationpredominantintheupperlobes.
Case2COVID-
consolidationswithupperlobe-predominantdistribution
A62-year-oldmanwithaone-weekhistoryoffever,dys-
andahistoryofhumidifierusagewerevitaltothediagnosis.
pnoea,andthroatdiscomfortwasadmittedtoourhospital.
Thehumidifierlungwasfirstreportedinthe1970sasa
LaboratorydatashowedthatthelevelsoftheWBCcount,
phenotypeofhypersensitivitypneumonitisassociatedwith
LDH,CRP,andKL-6were8300/μL,290U/L,,
alarge-scalehumidifiersystemandwasmainlyconsidered
and570U/mL,-
anoccupationaldiseaseuntilrecently[2].Theincidence
segmentalGGOandperipherallinearconsolidationspre-
rateisapproximately10%amongexposedpeople[3].In
dominantlyonbothupperlobes().Westrongly
Japan,%ofhypersensitivitypneumonitiswasreported
suspectedCOVID-,repeatedPCRandblood
tobehumidifierlung,whichmayhaveincreasedinrecent
yearswiththewideuseofdomesticultrasonichumidifiers
hadahistoryofultrasonichumidifieruse,andhadnot
[4,5].Aseasonalincreaseinthecasesofhumidifierlung
changedthewaterorcleanedthetanksformorethana
hasbeenreportedinthewintermonthsofDecemberto
FebruaryinJapan,whenultrasonichumidifiersareused
,
topreventdryindoorenvironments[6].Fever,cough,and
hisconditionresolvedwithimprovedchestCTfindings
dyspnoeaarecommonsymptoms[3].Microorganisms
andhehasnotexperiencedanysymptomrelapsewithout
suchasfungiandbacteriagrowinsidetheultrasonic
pharmacologicaltherapies.
humidifierswhenthewaterisnotreplaced,orthetankis
-
Discussion
ismshavebeenreportedtocauseallergicreactionsthat
Here,-
humidifierlungwhowereinitiallysuspectedofhavingtaminatedwaterinthehumidifiertankissuggestedto
2©&SonsAustralia,Ltd
onbehalfofTheAsianPacificSocietyofRespirology.
-19
induceseverelunginjury[5].Therefore,antibioticagentsUltrasonichumidifierlungisnotwellrecognizedandmay
,thereisnoreporton
-19.
beeffectiveinseverelunginjury[2,6].CharacteristicCTfindingsandahistoryofultrasonic
Thetwopatientsofthisstudywerefinallydiagnosedashumidifierusearecriticalinmakingthisdistinction.
humidifierlung,andtheirCTfindingsweresimilarto
COVID-
DisclosureStatement
inthediagnosisofCOVID-19,chestCTisusedtocomple-
mentthediagnosisinendemicareas,owingtoitshighAppropriatewritteninformedconsentwasobtainedfor
sensitivity(97%)[7].TypicalCTfindingsofCOVID-19publicationofthiscasereportandaccompanyingimages.
includethepresenceofGGOsalone(%)andwithcon-
solidations(%),withpredominantdistributioninAuthorContributionStatement
bilateral,peripheral/subpleural,andlowerlobes[8].How-
ever,CThaslowspecificity(25%),andtherefore,
importanttodifferentiateCOVID-,AtsushiKitamura,Tor-
-ahikoJinta,andNaokiNishimurarevisedandeditedthe
ifierlungarecharacterizedbyGGO(%),
nodules(%),peribronchovascularorsubpleuralnon-themanuscripttobepublished.
segmentalconsolidations(%),mosaicattenuation
(%),andsubpleuralcurvelinearopacity(%).References
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onbehalfofTheAsianPacificSocietyofRespirology.