1 / 15
文档名称:

Swallowing‐related neural oscillation an intracranial EEG study 2021 Hiroaki Hashimoto.pdf

格式:pdf   大小:9,489KB   页数:15页
下载后只包含 1 个 PDF 格式的文档,没有任何的图纸或源代码,查看文件列表

如果您已付费下载过本站文档,您可以点这里二次下载

Swallowing‐related neural oscillation an intracranial EEG study 2021 Hiroaki Hashimoto.pdf

上传人:一主三仆 2023/2/1 文件大小:9.27 MB

下载得到文件列表

Swallowing‐related neural oscillation an intracranial EEG study 2021 Hiroaki Hashimoto.pdf

相关文档

文档介绍

文档介绍:该【Swallowing‐related neural oscillation an intracranial EEG study 2021 Hiroaki Hashimoto 】是由【一主三仆】上传分享,文档一共【15】页,该文档可以免费在线阅读,需要了解更多关于【Swallowing‐related neural oscillation an intracranial EEG study 2021 Hiroaki Hashimoto 】的内容,可以使用淘豆网的站内搜索功能,选择自己适合的文档,以下文字是截取该文章内的部分文字,如需要获得完整电子版,请下载此文档到您的设备,方便您编辑和打印。:.
RESEARCHARTICLE
Swallowing-relatedneuraloscillation:anintracranialEEG
study
HiroakiHashimoto1,2,3,KazutakaTakahashi4,SeijiKameda1,FumiakiYoshida1,5,
HitoshiMaezawa1,SatoruOshino6,NaokiTani6,HuiMingKhoo6,TakufumiYanagisawa6,
ToshikiYoshimine3,HaruhikoKishima6&MasayukiHirata1,3,6
1DepartmentofNeurologicalDiagnosisandRestoration,GraduateSchoolofMedicine,OsakaUniversity,Yamadaoka2-2,Suita,Osaka,565-0871,
Japan
2DepartmentofNeurosurgery,OtemaeHospital,Chuo-kuOtemae1-5-34,Osaka,Osaka,540-0008,Japan
3EndowedResearchDepartmentofClinicalNeuroengineering,GlobalCenterforMedicalEngineeringandInformatics,OsakaUniversity,
Yamadaoka2-2,Suita,Osaka,565-0871,Japan
4DepartmentofOrganismalBiologyandAnatomy,TheUniversityofChicago,1027E57thSt,Chicago,IL,60637
5DepartmentofAnatomyandPhysiology,SagaMedicalSchoolFacultyofMedicine,SagaUniversity,Nabeshima5-1-1,Saga,Saga,849-8501,Japan
6DepartmentofNeurosurgery,GraduateSchoolofMedicine,OsakaUniversity,Yamadaoka2-2,Suita,Osaka,565-0871,Japan
CorrespondenceAbstract
HiroakiHashimoto,Departmentof
NeurologicalDiagnosisandRestoration,Objective:Swallowingisauniquemovementduetotheindispensableorches-
GraduateSchoolofMedicine,
University,Yamadaoka2-2,Suita,
565-0871,:+81-6-6210-8429;Fax:thattheunderlyingneuralmechanismofswallowingwouldberevealedby
+81-6-6210-8430;E-mail:h-high-:Eightepilepticparticipantsfitted
******@-
MasayukiHirata,DepartmentofNeurological
DiagnosisandRestoration,GraduateSchoolwaterbolusandcorticaloscillatorychanges,includingthehighcband(75–
ofMedicine,OsakaUniversity,Yamadaoka2-150Hz)andbband(13–30Hz),wereinvestigatedatthetimeofmouthopen-
2,Suita,Osaka565-0871,:+81-6-ing,waterinjection,:Increasesinhighcpowerassoci-
6210-8429;Fax:+81-6-6210-8430;E-mail:atedwithmouthopeningwereobservedintheventrolateralprefrontalcortex
******@-(VLPFC)withwaterinjectioninthelateralcentralsulcusandwithswallowing

FundingInformationpower,
ThisworkwassupportedbytheJapanofactivitywasfocalandspecifictoswallowing;however,thebactivitieswere
SocietyforthePromotionofScience(JSPS)
KAKENHI[(Masayukiinvoluntaryswallowing,swallowing-relatedhighcpowerachieveditspeak,and
Hirata),JP18H04166(MasayukiHirata),subsequently,:Wedemonstratedthreedis-
JP18K18366(HiroakiHashimoto)],bythetinctactivitiesrelatedtomouthopening,waterinjection,andswallowing

Communications(MasayukiHirata),byarelatedtoswallowingsuggeststhatduringvoluntaryswallowingphases,thecor-
grantfromtheNationalInstituteof
InformationandCommunicationsTechnologytexisthemaindrivingforceforswallowingasopposedtothebrainstem.
(NICT)(MasayukiHirata),andbyagrant
fromtheNationalInstituteofDentaland
CraniofacialResearch(NIDCR)-RO1
DE023816(KazutakaTakahashi).
Received:14January2021;Revised:26
February2021;Accepted:2March2021
doi:
ª
ThisisanopenaccessarticleunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsuse,distributionandreproductioninany
medium,:.
Swallowing-.
IntroductionfMRIhashighspatialresolution,intheorderofmillime-
ters;however,-
Swallowingisaprimitiveandfundamentalfunction,asporalresolutionofMEGishigh,intheorderof
wellasauniquemovementbecausethecooperationmilliseconds19;however,itsspatialresolutionislimited.
betweenvoluntaryandinvoluntarymovementsisneces-Noninvasivemethodshaveeitherweaktemporalorspa-
,theswallowingmove-tialresolution;therefore,weinferredthatsuchmethods
mentisdividedintotwocomponents:voluntaryhadapotentiallimitationfortheinvestigationofneural
-
processingrelatedtoswallowingthattransitionsfromthe
texisassumedtoplayacrucialroleinswallowingmove-voluntarytoinvoluntaryphaseintheorderofmillisec-
,22
triggersswallowingandmodulatesthebrainstem,whereIntracranialEEGs(iEEGs),suchaselectrocorticograms
thecentralpatterngenerator(CPG)forswallowingis(ECoGs),thatrecordneuralactivitiesdirectlyfromthe
,cerebral
3corticalsurfaceofthebrainenableustomeasureneural
cortexdamageduetostrokeorneurodegenerativedis-,
ease4promotesswallowingdisturbance(dysphagia).
usingECoG,wecanmeasurehigh-frequencyneuraloscil-
Theadoptionofdifferentposturesandmodificationoflations,includinghighcbands(>50Hz).Highcactivity
thebolusconsistencyarewidelyacceptedinclinicalprac-isakeyoscillationthatreflectstheneuralprocessingof
–25
sensory,motor,
stimulation,suchaspharyngealelectricalstimulation6or
alsoshowbetterfunctionallocalizationthanthatinlower
transcutaneousneuromuscularstimulation,7andnoninva-23
frequencybandsandhavecometobeknownasuseful
sivebrainstimulationusingrepetitivetranscranialmag-,wehypothe-
neticstimulation(rTMS)8ortranscranialdirectcurrent
sizedthattheanalysisofhighcactivitiesacquiredby
stimulation(tDCS)9arealsobeingstudiedasemerging
ECoGmeasurementswouldbeabletorevealswallowing-
-
fortheseneuromodulationstrategiesfordysphagia;how-
ever,variousintensitiesanddurationshavebeenusedforprovideneuromodulationstrategiesfordysphagiawith
stimulation,10andthebestconditionsforstimulation
beneficialinformation,suchasbrainareasandtimingfor
,thetreatmenteffectsofthesestimulation,thatwillenableustoachievebetterresults.
neuromodulationtherapiesremainlimited,andfurther
studiesarerequiredtoprovideevidenceforovercoming

Wehavecontinuedtoresearchandcontributetothe
fieldofneuromodulationfordysphagiausingourbrain-Participants
machineinterface(BMI),wedevelopedEightpatientswithintractabletemporallobeepilepsypar-
anovelswallow-trackingsystemthatenabledustononin-ticipatedinthisstudy(fourfemales,15–51yearsofage;
,we
)
demonstratedthatdeeptransferlearningappliedto(Table1).TheywereadmittedtoOsakaUniversity
intracranialelectroencephalogram(EEG)signalswasableHospitalfromApril2015toJuly2019andunderwent
-
intracranialelectrodeplacementforaninvasiveEEG
,whichwas
orperipheralorgansregardlessofpatients’
-
executedbythepatients’swallowingintention,ahighersibleconsequencesofthisstudyandwritteninformed
degreeofrecoverywouldbeobtainedbysensoryneuro-
(Nos.
stimulationtriggeredbypatients’,16469).
Theelucidationofswallowing-relatedneuralprocessing
isessentialfortherealizationofsuchaswallow-assisting
,suchasscalpEEG,13positronIntracranialelectrodes
emissiontomography(PET),14near-infraredspectroscopy
1516Foranalysis,wechoseplanar-surfaceplatinumgridelec-
(NIRS),TMS,functionalmagneticresonanceimagingtrodes(495contactsarray)thatwereplacedoverthe
(fMRI),17,18andmagnetoencephalography(MEG),19,20
lateralportionofthecentralsulcuscorrespondingtothe

2ª:.
-RelatedNeuralOscillation
.
NumberoforofacialcontactsNumberofswallowingNumberofmouthopeningNumberofwater
ParticipantSexAgeSide(totalcontacts)instancesinstancesinjections
P1F36L18(68)313131
P2F30L20(84)414141
P3F18R18(55)272727
P4M24L15(69)343434
P5M51L20(72)383838
P6M28R20(96)272727
P7M20L20(94)333333
P8F15L20(68)373737
M,Male;F,Female;R,Right;L,Left.
obtainedfromtheCTimageswereoverlaidontothe3-withthefollowingswallowingstages:stageI(theoral
dimensionalbrainrenderingsfromtheMRIvolumethatstage),stageII(thepharyngealstage),andstageIII(the
wascreatedbyFreeSurfersoftware().ThetimeoftheEGGpeakcorre-
).WeobtainedtheMontrealNeurologi-
calInstitute(MNI)coordinatesoftheimplantedcontactstheoralphaseisvoluntarilycontrolledandthepharyn-
withBrainstormsoftware(,1
instorm/).
thetransitiontimefromvoluntaryswallowingtoinvolun-
taryswallowing().Wecouldalsodetectthetime
Taskandswallowingmonitoring
whentheparticipantopenedhis/hermouthandwhenthe
Theparticipantswereaskedtositonachairandthenexaminerinjectedwaterintotheparticipants’mouth
opentheirmouths,andtheexaminerinjected2mLofusingthevideocapturedbytheRGBcameraofKinect
,whichcorre-
Fornoninvasiveswallowingdetection,weusedanelec-spondedtodifferenttimes,werealsoinsertedintoiEEG
troglottograph(EGG),amicrophone,andamotion-data(thenumberofeachtriggerisshowninTable1).
trackingsystem().Alaryngograph(LaryngographDetailsareprovidedintheDataS1.
Ltd,London,UK)wasusedasanEGGandrecordedthe
neckimpedancechangesassociatedwithswallowing26
Dataacquisitionandpreprocessing
().Soundsofswallowingduetotheboluspassing
throughthepharynxweredetectedbyathroatmicro-TheiEEGsignalsweremeasuredwitha128-channeldigital
phone27().WeconnectedthethroatmicrophoneEEGsystem(EEG2000;NihonKohdenCorporation,
(Inkoumike;SH-12iK,NANZU,Shizuoka,Japan)totheTokyo,Japan).Beforeanyfurtherprocessing,contactscon-
.
Wecapturedthemotionoftheparticipantsat30Throughoutthefollowinganalyses,aband-passfilterusing
framespersecondwiththemotion-trackingsystem,atwo-wayleast-squaresfiniteimpulseresponsefilter
whichwasnewlydevelopedbyususingKinectv2(Micro-(,
soft,Redmond,Washington,USA).11)wasappliedtothe
Anelectricstimulator(NS-101;UniqueMedical,.
Tokyo,Japan)supplieddigitalsynchronizingsignalsto
thelaryngographanda128-channeldigitalEEGsystem.
Spectralanalyses
Themultimodaldataweresynchronizedandenabledus
-frequencyanalysisofthetime-lockediEEGsignals
-
quencyrangefrom1to330Hzandspectralpower(in
dB)

最近更新

业务流程外包项目实施方法探究的任务书 3页

2024年读女巫的读后感7篇 9页

粪便、浆膜腔积液检验实验 23页

2024年语言关于雨的教案最新7篇 19页

米老师脾胃病讲座 30页

下水道污水水质转化机理研究与数值模拟的中期.. 2页

2024年花朵的教案7篇 16页

2024年艺术学校年度工作总结7篇 151页

管理生产计划与交期 25页

三维激光扫描数据可视化技术研究的中期报告 1页

纺织行业的科技创新与产业升级 26页

管理心理学态度与挫折管理之压力管理 23页

安徽省合肥市海恒中学2022-2023学年高二化学下.. 9页

一类奇异波方程的爆破理论及解分析的中期报告.. 1页

2024年精选热门关于科研工作总结范文8篇 23页

一种自适应入侵防御系统的研究和设计的任务书.. 2页

纺织品设计与时尚产业的关系研究 23页

变频器维修培训了解变频器的工作原理和故障排.. 28页

2024年精选关于20环保工作计划范文参考3篇 8页

变电站工程接地网敷设安装施工安全技术交底 31页

纺织品的功能性与特殊用途开发 30页

纺织品染色技术全解析 27页

赵姓研究报告范文五年级 2页

国家电网招聘之财务会计类题库及完整答案(历.. 222页

机械成孔灌注桩施工工艺方案 10页

挖掘机操作手册 11页

机加工岗位职责内容 2页

亨斯迈产品目录--中文 6页

中国文脉-中国文脉txt下载 5页

基本要道讲义 48页