文档介绍：奥美拉唑的配伍禁忌
注射用奥美拉唑钠与传染病科常用药物配伍结果
摘要目的:研究奥美拉唑钠与24种传染病科常用药物配伍结果。方法:将奥美拉唑钠分别与24种药物进行配伍,在不同的时间观察其外观变化,测定其ph值和吸收度。结果:奥美拉唑钠与奥曲肽、思美太、还原型谷光甘肽、11-氨基酸、精氨酸、酚磺乙***等15种药物存在配伍禁忌;与促肝细胞生长素、乙酰谷酰***、病毒唑、清开灵、生脉、参脉、甘利欣、华蟾素、单磷酸阿糖腺苷配伍后稳定性无明显改变。结论:奥美拉唑钠与传染病科常用药物配伍禁忌发生率高,值得临床注意。
关键词奥美拉唑钠配伍禁忌传染病稳定性
Abstract: Objective: It is to study the patibility of Omeprazole and 24 kinds of infectious diseases drugs mon use. Methods:After Omeprazole was respectively made to do the mixing with 24 kinds of drugs ,observe the appearances and measure pH scale and absorption. Results: Turbidity appeared or color changed in Octreotide, Ademetionine, Reduced Glutathione, 11-Amino Acid, Arginine,
Etamsylate, Tiopronin ect 15 kinds of drugs after mixing. The stabitities did not chang abviously in Hepatocyte Growth-promoting Factors, Aceglupamide, Virazole,Qingkailing, Shengmai, Shenmai, Diammonium Glycyrrhizinate Injection, Huachansu, Vidarabine Monophosphate 9 kinda of drugs after mixing. Conclusion: The rate of Omeprazole patibility is
high. So it is worth to pay attention in clinic.
Key words: Omeprazole patibility infectious diseases stability
注射用奥美拉唑钠(商品名洛赛克、奥西康等)是近年来开发的抗消化性溃疡药,广泛应用于消化性溃疡、急性胃粘膜病变及其所致的上消化道出血。肝炎、肝硬化病人合并消化性溃疡病(旧称***性溃疡)、消化道出血者比较多,比普通人群高20%【1】,故奥美拉唑钠为传染病科常用药,其疗效迅速可靠,但在配伍用药和更换输液瓶时发现该药与与多种药物发生浑浊、变色等反应,而在药物说明书、药典及《256种注射液配伍检索表》中均不能查到其配伍禁忌。为指导临床合理、安全用药,减少浪费,我们将奥美拉唑钠与24种传染病科常用药物进行了配伍研究。现报告如下。
(一) 材料