文档介绍：结直肠癌术后早期应用奥沙利铂联合5
凌瑞,张洪伟,李纪鹏, 王为忠
【关键词】结肠直肠肿瘤
Safety of postoperative application of oxaliplatin bined otherapy, oxaliplatin bined y. METHODS: Thirtysix patients ized into tent group received adjuvant chemotherapy using oxaliplatin bined y; otherapy. The tolerances of chemotherapy, the impact on ined. RESULTS: The healing condition of otherapy induced nausea and vomiting all numbers of patients in the treatment group, but etic therapy. Neutropenia ent group or control group. In addition, both groups shoe change of IL2 and sIL2R. CONCLUSION: Early application of adjuvant chemotherapy using oxaliplatin bined y. It has no influence on the patients healing ability and ptoms after operation. Furthermore, adjuvant chemotherapy doesn't influence patients immune system and then ore, early application of adjuvant chemotherapy in patients after colorectomy can positively prolong the survival time and delay the recurrence.
【Keys; oxaliplatin; chemotherapy, adjuvant; timing
【摘要】目的: 对大肠癌术后早期应用奥沙利铂(乐沙定)联合5FU/甲酰四氢叶酸辅助化疗的安全性进行探讨. 方法: 将36例行根治术的Ⅲ期大肠癌患者随机分为2组,治疗组于术后第4日开始应用奥沙利铂联合5FU/甲酰四氢叶酸辅助化疗,观察患者化疗反应情况、术后切口愈合状况和血清IL2, sIL2R的变化,对照组不做化疗. 结果: 两组切口愈合状况无明显差异,化疗组有少数患者出现恶心、欲吐现象,经对症处理后症状基本消失,白细胞水平下降不显著,术后两组IL2和sIL2R的变化趋势相同. 结论: 大肠癌术后早期应用奥沙利铂联合5FU/甲酰四氢叶酸辅助化疗,不会影响患者切口愈合能力和增加术后并发症,对患者的免疫功能影响不大,对延长大肠癌患者的生存期,延缓术后复发可能会起到积极的作用.
【关键词】结肠直肠肿瘤;奥沙利铂;化学疗法,辅助;时机
0引言
大肠癌术后辅助化疗已受到了医学界的广泛重视,大量的基础和临床研究证实,