文档介绍：多指标优选银桑降糖颗粒辅料研究
[摘要]该文通过研究各辅料对提取物的吸湿性影响,对制剂内多糖测定的干扰以及对小鼠血糖值的影响筛选了辅料种类,采用单因素试验法,以吸湿性,成型性和流动性为指标,测定了吸湿量,颗粒得率以及休止角,结合物料外观性状,筛选了辅料配比及用量,并测定了颗粒的相对临界湿度。优选的银桑降糖颗粒最佳辅料为桑叶清膏微晶纤维素四角蛤蜊粗多糖10∶9∶167,所得颗粒成型性,流动性好,且不易吸潮液化,其相对临界湿度为73%。经研究优选所得银桑降糖颗粒制剂工艺和处方科学可行,可以明显改善提取物易吸湿液化的性质,提高制剂稳定性,适合工业化生产,并为其他制剂筛选辅料提供借鉴。
[关键词]银桑降糖颗粒; 辅料; 吸湿性; 液化
Optimize excipients for Yinsang hypoglycemic granules by using multiple indexes
DU Junchao1,2, CHENG Jianming1,2, LIU Rui1,2, WANG Xinzhi1,2, ZHANG Qian1,2, ZHANG Wenying1,2, WU Hao1,2*
(1Jiangsu Key Laboratory of Research and Development in Marine Bioresoure Pharmaceutics, Nanjing University of
Chinese Medicine, Nanjing 210023, China;
2Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China)
[Abstract]Optimal excipients were screened by studying the effect of different excipients on the hygroscopicity of the extract, testing haride in the preparation and blood glucose value Single factor tests were performed with hygroscopicity, formability and fluidity as the indexes, and the moisture content, granule yield and angle of repose bined with physical characters of the materials to screen the proportioning and dosage of excipients Then the critical relative humidity of preferred Yinsang granules were measured The optimum excipients for Yinsang hypoglycemic granules were mulberry leaf pastemicr