文档介绍：结直肠癌术后早期应用FOLFOX方案辅助化疗的临床评价
乙肝病毒感染与大肠癌肝转移关系
作者:符真符国珍彭勃
【摘要】目的探讨乙肝病毒感染与大肠癌肝转移的关系。方法回顾性分析1996年1月~2005年12月收治的大肠癌患者386例,比较乙肝病毒感染的大肠癌和非乙肝病毒感染的大肠癌两组肝转移的发生率。%,%,两者相比差异显著(P<)。结论乙肝病毒感染的大肠癌肝转移发生率比非乙肝病毒感染组低,前者很少发生肝转移。
【关键词】乙肝病毒结直肠肿瘤肝转移
Relationship between hepatic metastasis and hepatitis B virus infection in colorectal cancer.
FU Zhen, FU Guo-zhen,PENG Bo.
(Haikou Municipal People’s Hospital, Haikou 770208, Hainan, P. R. China)
Abstract:Objective To explore the relationship between HBV infection and hepatic melastasis of colorectal cancer. Methods Three hundred and eighty-six cases with colorectal cancer were retrospectively analyzed from January 1996 to Decemer 2005,and the prevalence of hepatic metastasis of colorectal cancer in patients with and without hepatitis B virus infection pared. Results In the HBV carriers, the prevalences of hepatic
metastasis were % and that in non-HBV carriers was %, showing significant difference between the two groups (P<). Conclusion The prevalence of homochronous hepatic metastasis and heterochronous hepatic metastasis of colorectal cancer in patients with HBV infection is lower than that of non-HBV infection metastasis of colorectal cancer is infrequent in pateints with HPV infection.
Key words:Hepatitis B virus; Colorectal cancer; Hepatic metastasis
有报道临床确诊为结直肠癌时,已有20%~40%发性肝转移[1]。为探讨乙肝病毒感染与大肠癌肝转移中所起作用,本文对我院自1996年1月~2005年12月收治的大肠癌患者386例,有82例并发肝转移,其中大肠癌并乙肝病毒感染者发生肝转移5例,现对其回顾性分析、探讨。
1 资料与方法
一般资料 386例患者中,男234例,女152例,年龄22~86岁,平均61岁。HBsAg阳性者(即感染组)58例,阴性者(即非感染组)328例。
治疗 82例肝转移者58例行原发灶切除。肝转移灶同时切除20例,微波固化9例,无水酒精注射21例,单独或同时行肝动脉插管化疗32例。
。
2 结果
有82例并发肝转移,转移癌数目不等,其中HBV感染者并发肝转移占
%(5/58),%(77/328)。术前B超或/并CT检查发现肝转移68例,其余14例术中探查时病理确诊;82例大肠癌肝转移者AFP均正常,%(82/386)。肝转移部位:左右两叶18例,左叶28例,右叶36例;单个转移结节16例,2~4个转移结节34例,≥5个转移结节32例;其它部位(包括肺、骨等的远外转移及腹膜种植转移)转移情况,感染组19%(11/58),%(66/328),两组差异无显著