文档介绍：第 33 卷第 4 期 2010 年 8 月- 263 -
超声量化技术在大鼠脂肪肝模型中应用的初步研究
徐旭,席文恭,王维亭,赵专友,汤立达
天津药物研究院天津药代动力学与药效动力学省部共建国家重点实验室,天津 300193
摘要目的:探讨超声量化技术评价大鼠肝脏脂肪变的价值。方法:大鼠 ig 酒精高脂乳液 12 周,制备脂肪肝模型。测量
正常大鼠及模型大鼠肝脏二维声像图的灰度值,检测肝组织三酰甘油(TG)、总胆固醇(TC),并将肝脏组织做病
理切片,观察肝细胞脂变情况。结果:与正常组比较,模型组超声图像近区、远区灰度显著增加,肝脏 TG、TC
明显升高。组织病理学分析可见模型大鼠肝脏典型脂肪样变。结论:超声量化技术可作为一种无创性量化方法用于
判断大鼠肝脏脂肪变化。
关键词超声检查;量化;灰阶强度;脂肪肝
中图分类号: 文献标志码:A 文章编号:1674–6376(2010)04–0263–04
Preliminary study on application of the quantitative ultrasonic diagnostic
technique in the study on a rat model of fatty liver disease
XU Xu, XI Wen-gong, WANG Wei-ting, ZHAO Zhuan-you, TANG Li-da
Tianjin State Key Laboratory of ics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin
300193, China
Abstract Objective: To explore the quantitive assessment of fatty liver of rats by measuring ultrasonic gray scale. Methods: A
posed of alcohol, lard and cholesterol was supplied to rats for 12 weeks in order to establish a rat model of
hepatic steatosis. To measure ultrasonic gray scale of liver and hepatic pathological feature liver, and the changes of the
contents of triglyeeride (TG) and cholesterol (TC) in liver tissue were observed. Results: Gray scale from near or far areas
of ultrasonic image in model rats was higher than that of normal rats. And the rats of fatty liver diseases had a significantly
higher