文档介绍：直肠癌术前淋巴化疗安全性分析
直肠癌术前淋巴化疗安全性分析
作者:孟强孟荣贵崔龙凌光烈刘冰作者单位:110001 沈阳,中国医科大学附属第一医院肛肠外科; 200433 上海,第二军医大学长海医院肛肠外科
【摘要】目的研究直肠癌患者术前淋巴化疗应用的安全性。方法观察淋巴化疗后局部和全身症状、心肝肾及造血功能变化、术后吻合口愈合情况以及检测淋巴化疗前30 min和淋巴化疗后48 h血CD3+、CD4+、CD8+、CD4+/CD8+、CD(16+56)+。结果淋巴化疗对局部和全身症状、心肝肾及造血功能、术后吻合口愈合无明显影响;比较淋巴化疗前30 min与淋巴化疗后48 h,CD4+/CD8+升高(t=,P<),CD3+、CD4+、CD8+、CD(16+56)+无明显变化(t=,,,,P>)。结论淋巴化疗具有安全性,短期内对机体免疫有一定促进作用。
【关键词】直肠肿瘤; 淋巴化疗
Clinical safety of preoperative lymphatic chemotherapy in the treatment of rectal cancer MENG Qiang, MENG Rong-gui, CUI Long, LING Guang-lie, LIU Bing. Department of Colorectal Surgery, First Affiliated Hospital of China Medical University, Shengyang 110001, China
【Abstract】 Objective To investigate the clinical safety of preoperative lymphatic chemotherapy in the treatment of rectal cancer. Methods The regional and systemic symptoms, postoperative stoma healing, haematogenesis, functions of heart, liver and kidney after lymphatic chemo
therapy, and the level of CD3+, CD4+, CD8+, CD4+/CD8+, CD(16+56)+ in blood 30 minutes before and 48 hours after lymphatic chemotherapy were detected. Results There were no significant effects of lymphatic chemotherapy on the regional and systemic symptoms, postoperative stoma healing, haematogenesis and the functions of heart, liver and kidney. The level of CD4+/CD8+ 48 hours after lymphatic chemotherapy was signif