文档介绍：考来烯***(消胆安)说明书-施贵宝
QUESTRAN LITE Powder
SCHEDULING STATUS
S2
PROPRIETARY NAME
(and dosage form):
QUESTRAN LITE Powder
COMPOSITION
Each sachet of QUESTRAN LITE powder contains 4 g or 8 g of anhydrous cholestyramine, the active ingredient. Each 4 g sachet contains 16,8 mg phenylalanine and each 8 g sachet contains 33,6 mg phenylalanine, from aspartame, as sweetener.
PHARMACOLOGICAL CLASSIFICATION
- Serum-cholesterol reducers.
PHARMACOLOGICAL ACTION
QUESTRAN LITE is the chloride salt of a basic anion-exchange resin, cholestyramine.
Cholestyramine is very hydrophilic, but it is not soluble in water, nor is it hydrolysed by digestive enzymes. Thus, QUESTRAN LITE is not absorbed from the intestinal tract.
Cholestyramine resin adsorbs bines with the bile acids in the
intestine to form an plex which is excreted in the faeces. The increased faecal loss of bile acids leads to an increased oxidation of cholesterol to bile acids and a decrease in serum cholesterol levels and low density lipoprotein cholesterol serum levels.
When administered properly, QUESTRAN LITE usually leads to a significant reduction (15% or more) in serum cholesterol levels.
In patients with pruritis associated with partial biliary obstruction the reduction of serum bile acid levels by QUESTRAN LITE is thought to reduce excess bile acids deposited in the dermal tissues and promote their excretion with the faeces. The relief from itching afforded to most of these patients by QUESTRAN LITE is attributed to this mobilisation. It is postulated that in "bile-salt" diarrhoea, QUESTRAN LITE binds conjugated dihydroxy bile salts which are known to have a cathartic effect.
INDICATIONS
For reduction of serum cholesterol and low density cholesterol, lipoprotein levels in primary
hypercholesterolaemia in conjunction with an appropriate diet. QUESTRAN LITE is indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hyper