文档介绍:分析化疗联合顺铂胸腔灌注治疗肺癌伴恶性胸腔积液的临床观察
本文采集自网络,本站发布的论文均是优质论文,版权和著作权归原作者所有。
[摘要] 目的探究化疗联合顺铂胸腔灌注治疗肺癌伴恶性胸腔积液的临床疗效。方法随机选取该院2014年1月―2016年12月收治的肺癌伴恶性胸腔积液患者60例,随机平分为两组。观察组患者采用化疗联合顺铂胸腔灌注治疗,对照组患者采用吉西他滨联合顺铂全身化疗。比对两组在治疗疗效、药物不良反应、生活质量的差异。%%(P<);两组不良反应以Ⅰ级、Ⅱ级为主,观察组患者在骨髓抑制、胃肠道反应、肝功能损伤等不良反应发生率与对照组差异无统计学意义(P>);%%,对比差异有统计学意义(P<),但顺铂胸腔灌注使胸腔粘连,致包裹性胸腔积液,引起胸闷、气喘、呼吸困难。结论顺铂胸腔灌注治疗疗效虽优于全身化疗,但顺铂胸腔灌注可使部分患者引起严重的包裹性胸腔积液,导致部分患者出现胸闷气喘、呼吸困难的不良反应,较大的影响患者生活?|量。因此,在治疗肺癌伴恶性胸腔积液治疗中可首选全身化疗。对于一般状况差,预计生存期短的患者,可采取胸腔灌注。
[关键词] 化疗;顺铂胸腔灌注;肺癌;恶性胸腔积液
[中图分类号] [文献标识码] A [文章编号] 1674-0742(2017)04(b)-0139-03
Analysis of Clinical Observation of Chemotherapy and Cis-platinum in the Thoracic Perfusion Treatment of Lung Cancer and Malignant Pleural Effusion
CHEN Lin, SUN Li-zhu
Department of Oncology, Shuyang People’s Hospital, Suqian, Jiangsu Province, 223600 China
[Abstract] Objective To study the clinical curative effect of chemotherapy and cis-platinum in the thoracic perfusion treatment of lung cancer and malignant pleural effusion. Methods 60 cases of patients with lung cancer and malignant pleural effusion admitted and treated in our hospital from January 2014 to December 2016 were selected and randomly divided into two groups, the observation group adopted the chemotherapy and cis-platinum thoracic perfusion treatment, while the cont